123054-35-3

Basic information

• Product Name: 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 3-iodo-8-oxo-7-[(phenylacetyl)amino]-, diphenylmethyl ester, (6R,7R)-
• CAS NO: 123054-35-3
• Molecular Formula: C28H23IN2O4S
• Molecular Weight: 610.472
• Mol File: 123054-35-3.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 3-iodo-8-oxo-7-[(phenylacetyl)amino]-, diphenylmethyl ester, (6R,7R)-(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 3-iodo-8-oxo-7-[(phenylacetyl)amino]-, diphenylmethyl ester, (6R,7R)-(123054-35-3)
• EPA Substance Registry System: 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 3-iodo-8-oxo-7-[(phenylacetyl)amino]-, diphenylmethyl ester, (6R,7R)-(123054-35-3)

Safety Data

• Hazardous Substances Data: 123054-35-3(Hazardous Substances Data)

Upstream product

• 54639-48-4 (6R,7R)-benzhydryl 3-hydroxy-8-oxo-7-(2-phenylacetamido)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate 
• 122553-60-0 (6R,7R)-benzhydryl 8-oxo-7-(2-phenylacetamido)-3-(((trifluoromethyl)sulfonyl)oxy)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate 

Downstream Products

• 371207-60-2 (R)-3-Iodo-7,8-dioxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester 
• 371207-96-4 (R)-5,5,8-Trioxo-7-[1-pyridin-2-yl-meth-(Z)-ylidene]-5λ⁶-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester 
• 460739-55-3 (R)-3-Iodo-8-oxo-7-[1-pyridin-2-yl-meth-(Z)-ylidene]-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester 
• 371207-94-2 (R)-3-Fluoro-5,5,8-trioxo-7-[1-pyridin-2-yl-meth-(Z)-ylidene]-5λ⁶-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester 
• 371207-64-6 (R)-3-Iodo-5,5,8-trioxo-7-[1-pyridin-2-yl-meth-(Z)-ylidene]-5λ⁶-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester 
• 371207-77-1 (R)-5,5,8-Trioxo-3-phenyl-7-[1-pyridin-2-yl-meth-(Z)-ylidene]-5λ⁶-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester 
• 371207-79-3 (R)-5,5,8-Trioxo-7-[1-pyridin-2-yl-meth-(Z)-ylidene]-3-thiophen-2-yl-5λ⁶-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester 
• 371207-87-3 (R)-5,5,8-Trioxo-3-phenylsulfanyl-7-[1-pyridin-2-yl-meth-(Z)-ylidene]-5λ⁶-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester 
• 460739-00-8 (R)-3-Methylsulfanyl-5,5,8-trioxo-7-[1-pyridin-2-yl-meth-(Z)-ylidene]-5λ⁶-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester 
• 501003-65-2 (R)-3-Methanesulfonyl-5,5,8-trioxo-7-[1-pyridin-2-yl-meth-(Z)-ylidene]-5λ⁶-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester 
• 501003-66-3 (R)-3-Benzenesulfonyl-5,5,8-trioxo-7-[1-pyridin-2-yl-meth-(Z)-ylidene]-5λ⁶-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester 
• 371207-56-6 (6R,7R)-7-Amino-3-iodo-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester 

Relevant articles and documents

Cephalosporin-derived inhibitors of beta-lactamase. Part 4: The C3 substituent.

New C3-substituted beta-lactamase inhibitors were prepared and evaluated against representative class A and class C enzymes. It was possible to improve simultaneous inhibitory activity of both classes of serine hydrolase. Other inhibitors showed high selectivity for either the class C cephalosporinases or the class A penicillinases. This represents the first time that cephalosporin-derived inhibitors have demonstrated selectivity for the class A beta-lactamases.

A General Route to 3-Functionalized 3-Norcephalosporins

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