1230559-20-2Relevant articles and documents
Piperazine sulfonamide BACE1 inhibitors: Design, synthesis, and in vivo characterization
Cumming, Jared,Babu, Suresh,Huang, Ying,Carrol, Carolyn,Chen, Xia,Favreau, Leonard,Greenlee, William,Guo, Tao,Kennedy, Matthew,Kuvelkar, Reshma,Le, Thuy,Li, Guoqing,McHugh, Nansie,Orth, Peter,Ozgur, Lynne,Parker, Eric,Saionz, Kurt,Stamford, Andrew,Strickland, Corey,Tadesse, Dawit,Voigt, Johannes,Zhang, Lili,Zhang, Qi
scheme or table, p. 2837 - 2842 (2010/08/04)
With collaboration between chemistry, X-ray crystallography, and molecular modeling, we designed and synthesized a series of novel piperazine sulfonamide BACE1 inhibitors. Iterative exploration of the non-prime side and S2′ sub-pocket of the enzyme culmin
