123061-49-4

Basic information

• Product Name: 2-(METHYLTHIO)-4-(TRIBUTYLSTANNYL)PYRIMIDINE
• Synonyms: 4-TRIBUTYLSTANNYL-2-THIOMETHYLPYRIMIDINE;2-(METHYLTHIO)-4-(TRIBUTYLSTANNYL)PYRIMIDINE;2-Methylthio-4-(tri-n-butylstannyl)pyriMidine, 96%;Pyrimidine, 2-(methylthio)-4-(tributylstannyl)-;4-(tributylstannyl)-2-(Methylthio)pyriMidine;2-Methylthiol-4-tributyltinpyMidine
• CAS NO: 123061-49-4
• Molecular Formula: C₁₇H₃₂N₂SSn
• Molecular Weight: 415.22
• Product Categories: Organostannes;Pyrimidine;Stannanes;organic tin
• Mol File: 123061-49-4.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 434.4 °C at 760 mmHg
• Flash Point: 216.5 °C
• Appearance: /
• Vapor Pressure: 2.41E-07mmHg at 25°C
• Storage Temp.: 2-8°C
• PKA: 0?+-.0.31(Predicted)
• CAS DataBase Reference: 2-(METHYLTHIO)-4-(TRIBUTYLSTANNYL)PYRIMIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(METHYLTHIO)-4-(TRIBUTYLSTANNYL)PYRIMIDINE(123061-49-4)
• EPA Substance Registry System: 2-(METHYLTHIO)-4-(TRIBUTYLSTANNYL)PYRIMIDINE(123061-49-4)

Safety Data

• Hazard Codes: Xi
• HazardClass: 6.1
• Hazardous Substances Data: 123061-49-4(Hazardous Substances Data)

Usage

General Description

2-(Methylthio)-4-(tributylstannyl)pyrimidine is a chemical compound that consists of a pyrimidine ring with a methylthio group at the 2 position and a tributylstannyl group at the 4 position. It is commonly used as a building block in organic synthesis and as an intermediate in the production of pharmaceuticals and agrochemicals. The tributylstannyl group makes it a useful reagent for cross-coupling reactions in organic synthesis, while the methylthio group can also serve as a directing group for selective functionalization of the pyrimidine ring. 2-(METHYLTHIO)-4-(TRIBUTYLSTANNYL)PYRIMIDINE is a valuable tool for chemists and researchers in the development of new molecules and materials.

InChI:InChI=1/C5H5N2S.3C4H9.Sn/c1-8-5-6-3-2-4-7-5;3*1-3-4-2;/h2-3H,1H3;3*1,3-4H2,2H3;/rC17H32N2SSn/c1-5-8-13-21(14-9-6-2,15-10-7-3)16-11-12-18-17(19-16)20-4/h11-12H,5-10,13-15H2,1-4H3

Upstream product

• 1122-74-3 4-iodo-2-(methylthio)pyrimidine 
• 49844-90-8 4-Chloro-2-methylthiopyrimidine 
• 1461-22-9 tributyltin chloride 
• 813-19-4 bis(tri-n-butyltin) 

Downstream Products

• 56734-10-2 2-(methylsulfanyl)-4-phenylpyrimidine 
• 1150111-43-5 2'-methylthio-N-(3-fluorophenyl)[4,4'-bipyrimidine]-6-amine 
• 1196552-10-9 (R)-6-(2-(3-fluorophenyl)pyrrolidin-1-yl)-3-(6-(2-(methylsulfinyl)pyrimidin-4-yl)pyridin-2-yl)imidazo[1,2-b]pyridazine 
• 1196552-09-6 (R)-6-(2-(3-fluorophenyl)pyrrolidin-1-yl)-3-(6-(2-(methylsulfonyl)pyrimidin-4-yl)pyridin-2-yl)imidazo[1,2-b]pyridazine 
• 1453852-65-7 (S)-2-(1-(4-chloro-3-fluorophenyl)-2-hydroxyethyl)-5-(2-(methylthio)pyrimidin-4-yl)pyridazin-3(2H)-one 
• 1239502-92-1 4-(2,4-dichlorophenyl)-2-[2-(methylsulfanyl)pyrimidin-4-yl]-5-(4H-1,2,4-triazol-3-yl)thiophene-3-carbonitrile 
• 1196552-08-5 (R)-6-(2-(3-fluorophenyl)pyrrolidin-1-yl)-3-(6-(2-(methylthio)pyrimidin-4-yl)pyridin-2-yl)imidazo[1,2-b]pyridazine 
• 401816-91-9 Methyl 4-{6-(trifluoromethyl)-2-[3-chlorophenyl]pyrazolo[1, 5-a]pyridin-3-yl}pyrimidin-2-yl sulfide 
• 401816-87-3 4-[2-(3-chloro-4-fluorophenyl)-6-(trifluoromethyl)pyrazolo[1,5-a]pyridin-3-yl]pyrimidin-2-yl methyl sulfide 
• 401816-83-9 methyl 4-{6-(trifluoromethyl)-2-[4-(trifluoromethyl)phenyl]pyrazolo[1,5-a]pyridin-3-yl}pyrimidin-2-yl sulfide 
• 401816-65-7 4-[2-(4-fluorophenyl)-6-(trifluoromethyl)pyrazolo[1,5-a]pyridin-3-yl]pyrimidin-2-yl methyl sulfide 
• 625095-86-5 N-cyclopentyl-2-(4-methoxyphenyl)pyrazolo[1,5-a]pyrimidin-7-amine 
• 528867-77-8 8-chloro-2-(4-fluoro-phenyl)-3-(2-methylsulfanyl-pyrimidin-4-yl)-imidazo[1,2-a]pyridine 
• 1298100-89-6 2-(S)-{[4-(4-methoxy-phenoxy)-2'-methylsulfanyl-[2,4]bipyrimidin-yl-5-ylamino]-methyl}-pyrrolidine-1-carboxylic acid tert-butyl ester 

Relevant articles and documents

Stannylation in the Electrophilic 2- and 4/6-Pyrimidine Position and the Use of Stannylpyrimidines in Coupling and Tin-Lithium Exchange Reactions

2-Stannylpyrimidines have been prepared by stannyl anion substitution in 2-chloropyrimidines.Stannylation in the 4-position was via the iodo-derivative or via the 4-lithio derivative and lithium-tin transmetallation.Tin-lithium exchange in the 2-position

THERAPEUTIC COMPOUNDS

The present invention provides compounds of formula (I): pharmaceutical compositions containing the same, processes for preparing the same and their use as pharmaceutical agents.