1230628-71-3Relevant academic research and scientific papers
Caspase inhibitors
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, (2016/12/16)
A compound, or a pharmaceutically acceptable salt or ester thereof, of formula I: X—W wherein X is a caspase-selective structure and W has the structure of —NH—CH(Y)(Z) wherein Y is
A highly potent and selective caspase 1 inhibitor that utilizes a key 3-cyanopropanoic acid moiety
Boxer, Matthew B.,Quinn, Amy M.,Shen, Min,Jadhav, Ajit,Leister, William,Simeonov, Anton,Auld, Douglas S.,Thomas, Craig J.
experimental part, p. 730 - 738 (2011/02/21)
Herein, we examine the potential of a nitrile-containing propionic acid moiety as an electrophile for covalent attack by the active-site cysteine residue of caspase 1. The syntheses of several cyanopropanate-containing small molecules based on the optimiz
