123064-91-5

Upstream product

• 138770-77-1 6-chloro-7,8-dimethoxy-1-methyl-1,3,4,5-tetrahydropyrrolo<4,3,2-de>quinoline 
• 1393471-49-2 2-(1-allyl-4-iodo-6-methoxyindolin-3-yl)acetonitrile 
• 1393471-40-3 tert-butyl 2-(1-allyl-4-iodo-6-methoxyindolin-3-yl)ethylcarbamate 
• 1393471-41-4 ethyl 3-(2-(tert-butoxycarbonylamino)ethyl)-4-iodo-6-methoxyindoline-1-carboxylate 
• 105908-35-8 6,7-dimethoxy-4-methylquinoline 
• 169901-29-5 6-Chloro-1-methyl-3,4-dihydro-1H-pyrrolo[4,3,2-de]quinolin-8-one 
• 1393471-50-5 C₁₄H₁₉IN₂O 
• 144085-18-7 1-allyl-4-iodo-3-(iodomethyl)-6-methoxyindoline 
• 1393471-46-9 6-chloro-7-methoxy-3,4-dihydropyrrolo[4,3,2-de]quinolin-8(1H)-one 
• 1393471-45-8 6-chloro-7-methoxy-1,3,4,5-tetrahydropyrrolo[4,3,2-de]quinoline 
• 1393471-47-0 ethyl 6-chloro-7-methoxy-4,5-dihydropyrrolo[4,3,2-de]quinoline-1(3H)-carboxylate 
• 1393471-44-7 5-tert-butyl 1-ethyl 6-chloro-7-methoxy-3,4-dihydropyrrolo[4,3,2-de]quinoline-1,5-dicarboxylate 
• 1393471-43-6 5-tert-butyl 1-ethyl 6-chloro-7-methoxy-2,2a,3,4-tetrahydropyrrolo[4,3,2-de]quinoline-1,5-dicarboxylate 
• 138770-70-4 [3-(Benzyloxycarbonyl-methyl-amino)-4,5-dimethoxy-phenyl]-carbamic acid 2-trimethylsilanyl-ethyl ester 

Downstream Products

• 138683-68-8 damirone B 

Relevant academic research and scientific papers

Total synthesis of makaluvamine A/D, damirone B, batzelline C, makaluvone, and isobatzelline C featuring one-pot benzyne-mediated cyclization- functionalization

Total synthesis of pyrroloquinoline alkaloids, such as makaluvamine A/D, damirone B, batzelline C, makaluvone, and isobatzelline C, was achieved featuring a one-pot benzyne-mediated cyclization-functionalization reaction. The synthetic utility was demonstrated by the construction of the common pyrrolo[4,3,2-de]quinoline skeleton.

Synthesis of pyrrolo[4,3,2-de]quinolines from 6,7-dimethoxy-4-methylquinoline. Formal total syntheses of damirones A and B, batzelline C, isobatzelline C, discorhabdin C, and makaluvamines A-D

2-Amino-4-nitrophenol and 2-methoxy-5-nitroaniline were converted into the 5-nitroquinolines 6b and 6d, respectively, and then the latter into nitro-acetal 6f. 6,7-Dimethoxy-4-methylquinoline (6g) was nitrated at C-5 and then the methyl substituent conver

Simple Total Syntheses of Marine Alkaloids, Batzelline C, Isobatzelline C, Damirone A, and Makaluvamine A

Batzelline C and isobatzelline C were synthesized in eight (or nine)steps from indole-3-carboxaldehyde.Syntheses of damirone A and makaluvamine A are also reported.

Synthetic studies on tetrahydropyrroloquinoline-containing natural products: Syntheses of discorhabdin C, batzelline C and isobatzelline C

Discorhabdin C (1), batzelline C (2) and isobatzelline C (3), metabolites of marine sources sharing a tetrahydropyrroloquinoline core, have been successfully synthesized, and cytotoxicities of several synthetic intermediates were evaluated.

Total Syntheses of Batzelline C and Isobatzelline C, the Novel Pyrroloquinoline Alkaloids Isolated from the Marine Sponge Batzella Sp.

Total syntheses of batzelline C and isobatzelline C, two chlorine-containing alkaloids have been successfully accomplished employing the tricyclic indole derivative as a key intermediate.