123067-91-4

Upstream product

• 58479-61-1 tert-butylchlorodiphenylsilane 
• 105966-43-6 3-tert-butyldiphenylsilyloxy-2-methylpropene 

Downstream Products

• 123067-97-0 (RS)-4-(tert-butyl-diphenyl-silanyloxy)-3-methyl-1-benzenesulfonyl-butan-3-ol 
• 177606-51-8 2-<(tert-butyldiphenylsilyloxy)methyl>prop-2-en-1-ol 
• 1012075-09-0 6-(tert-butyldiphenylsilyloxy)-5-methyl-2-methylenehexane-1,5-diol 
• 155191-60-9 (2RS)-3-(t-butyldiphenylsilyloxy)-1-iodo-2-methyl-2-(trimethylsilyloxy)-propane 
• 155191-58-5 (2RS)-1-bromo-3-(t-butyldiphenylsilyloxy)-2-methyl-2-(trimethylsilyloxy)-propane 

Relevant academic research and scientific papers

Direct preparation of allylstannanes from allyl alcohols: Convenient synthesis of β-substituted allylstannanes and of stereodefined γ-substituted allylstannanes

Primary allyl alcohols are converted into allyltributylstannanes in a one-pot operation. It entails (i) deprotonation with BuLi, (ii) sulfonylation with mesyl chloride, and (iii) nucleophilic substitution by LiSnBu3. Conversions are quantitative with isolated yields ranging from 70% to 100%. If the starting allyl alcohol contains a stereogenic double bond its configuration is retained.

Antibody drug conjugate, intermediate, preparation method, pharmaceutical composition and uses thereof

Disclosed are an antibody drug conjugate IB, which uses ether linkages for connection, and improves the water solubility, stability and cytotoxicity in vivo and in intro, and an intermediate, a pharmaceutical composition, and uses of the antibody drug conjugate. The antibody drug conjugate has simple synthetic steps and a high yield.