123089-03-2

Usage

Properties

1. Chemical compound
2. Molecular formula: C7H8BrN3O
3. Pyrimidine derivative
4. Contains a bromine atom and an allyloxy group
5. Used as an intermediate in the synthesis of pharmaceuticals and agrochemicals
6. Studied for potential biological activities
7. Potential applications as an anti-inflammatory and anticancer agent
8. Promising results in preclinical studies
9. Further research underway for potential applications in medicine and agriculture

Specific Content

2-allyloxy-5-bromopyrimidine is a chemical compound with the molecular formula C7H8BrN3O.
It is commonly used as an intermediate in the synthesis of various pharmaceuticals and agrochemicals.
2-allyloxy-5-bromopyrimidine has been studied for its potential biological activities, including its use as an anti-inflammatory and anticancer agent.
Promising results have been shown in preclinical studies, and further research is underway to explore its potential applications in medicine and agriculture.

Upstream product

• 38353-06-9 5-bromo-1H-pyrimidin-2-one 
• 107-18-6 allyl alcohol 
• 32779-36-5 5-Bromo-2-chloropyrimidine 

Relevant academic research and scientific papers

SULFONAMIDE DERIVATIVE AND PHARMACEUTICAL USE THEREOF

Provided is a sulfonamide derivative represented by the following general formula (1) and having an α4 integrin inhibitory effect with high selectivity with a low effect on α4β1 and a high effect on α4β7, or a pharmaceutically acceptable salt thereof (in the general formula (1), A, B, D, E, R41, and a to h are as described in the description).

One-pot etherification of purine nucleosides and pyrimidines

A one-pot synthesis of ethers derived from inosine, guanosine, 2′-deoxyguanosine, and pyrimidinones is described. Exposure of the heterocycle to 1H-benzotriazol-1-yloxy-tris(dimethylamino)phosphonium hexafluorophosphate (BOP) and Cs2CO3/s

Palladium Catalysis in Allylic Alkylations and Rearrangements in Pyrimidines

The regiochemistry of the alkylation of 2-pyrimidinones with ?-allylpalladium complexes from allylic acetates and Pd(0) depends on the substitution pattern in the allylic system.In Pd(II)-catalysed rearrangements of 2-propenyloxypyrimidines the preference for a 1,3-rearrangement or the Claisen 3,3-rearrangement is influenced by the substitution pattern in the allylic system.Pd(0) forms ?-allylpalladium complexes with 2-propenyloxypyrimidines which give rise to rearrangement products.The product ratios in the Pd(II) and Pd(0) rearrangements in unsymmetrically substituted allylic systems are different.The rearrangement reactions, especially the Pd(II) rearrangement, give access to products which are difficult to prepare by direct alkylation.