123093-92-5

Upstream product

• 100-53-8 phenylmethanethiol 
• 459-57-4 4-fluorobenzaldehyde 
• 867-13-0 diethoxyphosphoryl-acetic acid ethyl ester 

Downstream Products

• 113071-31-1 4-(4-Fluoro-phenyl)-2-isopropyl-5-phenyl-2,5-dihydro-thiophene-3-carboxylic acid ethyl ester 
• 123093-94-7 4-(4-fluorophenyl)-2-isopropyl-5phenyl-3-thiophene-carboxylic acid, ethyl ester 
• 113070-94-3 4-(4-fluorophenyl)-2-isopropyl-5-phenyl-3-thiophenemethanol 
• 123093-93-6 2-(diethoxyphosphinyl)-3-[2-(4-fluorophenyl)-2-oxo-1-phenylethyl]-thio-4-methyl-pentanoic acid, ethyl ester 

Relevant academic research and scientific papers

Synthesis of some highly functionalized thiophene-3-carboxylates and alcohols

Highly functionalized thiophenes are prepared by two methods. The first uses a lithium-halogen exchange reaction on a trisubstituted 5-bromothiophene 25 to generate the corresponding 5-lithiothiophene 26 which is then reacted with either dimethylformainide or formaldehyde to give the 5-formyl 28 or 5-hydroxymethylthiophene derivative 31 in good yields. These are further transformed to other tetrasubstituted thiophenes. The second method assembles the thiophene ring from three components: a benzyl mercaptan, an aldehyde, and a vinylphosphonate 10. Thus, the benzyl mercaptan is dilithiated then reacted with an appropriate aldehyde to afford a 2-mercapto-2-phenylethanol derivative 37. Michael addition of 37 to 10 followed by oxidation of the hydroxyl group furnishes ketophosphonate 39. An intramolecular Wittig-type reaction produces the thiophene skeleton.

Analogs of mevalonolactone and derivatives thereof

Compounds of the formula STR1 in which Y is STR2 X is O or S; Z is --CHOH--CH2 --CHOH--CH2 --COOH, an ester or salt thereof or the lactone thereof; and each of R1, R2 and R3 can be alkyl, cycloalkyl;