123100-66-3Relevant academic research and scientific papers
Novel approach to isoindolo[2,1-a]quinolines: Synthesis of 1- and 3-halo-substituted 11-oxo-5,6,6a,11-tetrahydroisoindolo[2,1-a]quinoline-10- carboxylic acids
Boltukhina, Ekaterina V.,Zubkov, Fedor I.,Nikitina, Eugenia V.,Varlamov, Alexey V.
, p. 1859 - 1875 (2005)
A series of 1- and 3-halo-substituted isoindolo[2,1-a]quinolines were obtained by means of electrophilic cyclization of methallyl- and allyl-substituted isoindolo-7-carboxylic acids. The influence of halogen atoms on the stereochemistry of the formation o
Scope of Tandem Cycloaddition/Radical Cyclization Methodology
Ghosh, Tirthankar,Hart, Harold
, p. 5073 - 5085 (2007/10/02)
Tandem cycloaddition/radical cyclization is an effective strategy for the rapid assembly of a wide variety of ring systems.To set up the reagents for this sequence, it is necessary to include a potential radical site in one of the two cycloaddition partners, located at an appropriate distance from a new double bond that will be formed in the cycloaddition step.Examples in which the cycloaddition step is or and in which the radical cyclization creates 5-, 6-, or 7-membered rings are described.Examples of the tandem methodology carried out in a completely intramolecular mode are also described.
