123100-73-2Relevant academic research and scientific papers
Scope of Tandem Cycloaddition/Radical Cyclization Methodology
Ghosh, Tirthankar,Hart, Harold
, p. 5073 - 5085 (2007/10/02)
Tandem cycloaddition/radical cyclization is an effective strategy for the rapid assembly of a wide variety of ring systems.To set up the reagents for this sequence, it is necessary to include a potential radical site in one of the two cycloaddition partners, located at an appropriate distance from a new double bond that will be formed in the cycloaddition step.Examples in which the cycloaddition step is or and in which the radical cyclization creates 5-, 6-, or 7-membered rings are described.Examples of the tandem methodology carried out in a completely intramolecular mode are also described.
