123101-27-9Relevant academic research and scientific papers
Stereochemistry of the Michael Addition of Ester and Ketone Enolates to α,β-Unsaturated Ketones
Oare, David A.,Heathcock, Clayton H.
, p. 157 - 172 (2007/10/02)
The stereo- and regiochemistry of addition of the enolates of ketones and esters to α,β-unsaturated ketones has been studied.There is a strong correlation between the enolate geometry and adduct stereostructure, with E enolates forming syn products and Z
INFLUENCE OF ENOLATE GEOMETRY ON THE STEREOCHEMISTRY OF MICHAEL ADDITIONS OF KETONE ENOLATES TO α, β-UNSATURATED KETONES
Oare, David A.,Heathcock, Clayton H.
, p. 6169 - 6172 (2007/10/02)
Preformed lithium enolates of ketones react with acyclic α,β-unsaturated ketones to give 1,5-diketones in good chemical yields.A strong correlation exists between enolate geometry and product stereochemistry; enolates having the Z configuration provide anti addition products while E enolates usually provide the syn diastereomers.
