123124-29-8Relevant academic research and scientific papers
Antiparasitic 5'-sulfamoyl nucleosides
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, (2008/06/13)
The triazole nucleosides 1-(5'-O-sulfamoyl-β-D-ribofuranosyl)[1,2,4]triazole-3-carboxamide, 1-(5'-O-sulfamoyl-β-D-ribofuranosyl)[1,2,4]triazole-3-thiocarboxamide and 1-(5'-O-sulfamoyl-β-D-ribofuranosyl)[1,2,4]triazole-3-carbonitrile are prepared and used as antiparasitic agents.
Synthesis, Structure, and Antiparasitic Activity of Sulfamoyl Derivatives of Ribavirin
Kini, Ganesh D.,Henry, Elizabeth M.,Robins, Roland K.,Larson, Steven B.,Marr, J. Joseph,et al.
, p. 44 - 48 (2007/10/02)
The triazole nucleoside derivatives 1-(5'-O-sulfamoyl-β-D-ribofuranosyl)triazole-3-carboxamide (2), 1-(5'-O-sufamoyl-β-D-ribofuranosyl)triazole-3-thiocarboxamide (3), and 1-(5'-O-sulfamoyl-β-D-ribofuranosyl)triazole-3-carbonitrile (4) were synthesized.Suitable protected triazole nucleosides were converted to their corresponding 5'-sulfamoyl derivatives, which on subsequent deprotection gave the desired compounds in good yields.The structures of compounds 2-4 were confirmed by X-ray crystallographic analysis.All three compounds showed significant activity in vitro, while 2 showed significant activity in vivo against Leishmania donovani and Trypanosoma brucei.
