1231255-97-2Relevant academic research and scientific papers
Access to Substituted Thiophenes through Xanthate-Mediated Vinyl C(sp2)-Br Bond Cleavage and Heterocyclization of Bromoenynes
Huang, Guoling,Li, Jian,Li, Jianrong,Li, Jiaming,Sun, Minghua,Zhou, Peng,Chen, Lu,Huang, Yubing,Jiang, Shaohua,Li, Yibiao
, p. 13037 - 13049 (2020/11/26)
An environmentally sustainable strategy for the chemoselective heterocyclization of bromoenynes through a transition-metal-free sulfuration/cyclization process is reported. Using inexpensive and safe EtOCS2K as a thiol surrogate and tetrabutylphosphonium bromide and H2O as a mixed solvent, the reaction provided a range of substituted thiophenes in moderate to good yields. In addition, 2,3,4,5-tetrasubstituted thiophenes were able to be prepared under mild reaction conditions by electrophilic heterocyclization with NH4I and EtOCS2K in good yields.
Expedient synthesis of functionalized conjugated enynes: Palladium-catalyzed bromoalkynylation of alkynes
Li, Yibiao,Liu, Xiaohang,Jiang, Huanfeng,Feng, Zhenning
supporting information; experimental part, p. 3338 - 3341 (2010/07/10)
(Chemical Equation Presented) Side by side: Direct cis addition of bro-moalkynes 1 to various alkynes 2 was found to proceed in the presence of a PdII catalyst to give difunctionalized enyne products 3. The method is facile for the synthesis of bromo alkenynes. Further-more, an unusual mechanism is pro-posed.
