123126-01-2

Basic information

• Product Name: 3'-mercapto-5'-O-DMT-3'-deoxythymidine
• Synonyms: 3'-mercapto-5'-O-DMT-3'-deoxythymidine
• CAS NO: 123126-01-2
• Molecular Weight: 560.671
• Mol File: 123126-01-2.mol

Chemical Properties

• CAS DataBase Reference: 3'-mercapto-5'-O-DMT-3'-deoxythymidine(CAS DataBase Reference)
• NIST Chemistry Reference: 3'-mercapto-5'-O-DMT-3'-deoxythymidine(123126-01-2)
• EPA Substance Registry System: 3'-mercapto-5'-O-DMT-3'-deoxythymidine(123126-01-2)

Safety Data

• Hazardous Substances Data: 123126-01-2(Hazardous Substances Data)

Upstream product

• 143527-01-9 1-(2'-deoxy-3'-O-mesyl-5'-O-4,4'-dimethoxytrityl-β-D-threo-pentofuranosyl)-thymine 
• 191474-13-2 5'-O-(4,4'-dimethoxytrityl)-2,3'-anhydrothymidine 
• 143527-02-0 Thiobenzoic acid S-[(2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester 

Downstream Products

• 1068144-70-6 3'-S-(4,4'-dimethoxytrityl)-3'-thiothymidine 
• 149510-50-9 C₄₉H₅₁N₅O₁₁S 
• 146961-96-8 C₄₂H₄₆N₄O₁₁S 
• 195967-04-5 C₄₇H₅₈N₄O₁₀S₂Si 
• 195967-05-6 C₄₁H₄₄N₄O₁₀S₂ 
• 195967-03-4 3'-deoxy-5'-O-dimethoxytrityl-3'-S-(5-nitropyridyl-2-disulfanyl)thymidine 
• 158944-83-3 C₅₉H₆₄N₄O₁₀SSi 
• 158944-92-4 C₅₉H₆₆N₄O₁₀SSi 
• 146961-99-1 C₅₇H₅₇N₅O₁₃S 
• 146961-95-7 C₅₄H₆₈N₄O₁₂S 

Relevant articles and documents

Solid-phase synthesis of oligodeoxynucleotides containing 3′-S-phosphorothiolate linkages

For the first time a fully automated procedure has been developed for the incorporation of a 3′-S-phosphorothiolate linkage into DNA, using phosphorothioamidite monomers. Coupling yields with either of the activators 5-ethylthiotetrazole or 4,5-dicyanoimi

Synthesis, dynamic combinatorial chemistry, and PCR amplification of 3'-5' and 3'-6' disulfide-linked oligonucleotides

Disulfide dithymidines linked 3'-5' or 3'-6' were synthesized and incorporated into oligonucleotides through a combined phosphotriester and phosphoramidite solid-phase oligonucleotide synthesis approach. The disulfide links are cleaved and formed reversibly in the presence of thiols and oligonucleotides. This link was shown to be sequence-adaptive in response to given templates in the presence of mercaptoethanol. The artificial 3'-5' and 3'-6' disulfide link was tolerated by polymerases in the polymerase chain reaction (PCR). By using sequencing analysis, we show that single mutations frequently occurred randomly in the amplification products of the PCR.

Reverse-direction (5′→3′) synthesis of oligonucleotides containing a 3′-S-phosphorothiolate linkage and 3′-terminal 3′-thionucleosides

The synthesis of oligodeoxynucleotides containing 3′-thionucleosides has been explored using a reverse-direction (5′→3′) approach, based on nucleoside monomers which contain a trityl- or dimethoxytrityl- protected 3′-thiol and a 5′-O-phosphoramidite. Thes

Dinucleoside monophosphate analogues containing disulfide linkages

Two dinucleoside monophosphate analogues containing disulfide linkages (1 and 2) have been prepared for incorporation into oligonucleotides. The modified oligomers will be tested for their potential as antisense agents.