123130-63-2Relevant academic research and scientific papers
A Scalable Protocol for the Regioselective Alkylation of 2-Methylcyclohexane-1,3-dione with Unactivated sp3 Electrophiles
Sharpe, Robert J.,Portillo, Maribel,Vélez, Robert A.,Johnson, Jeffrey S.
, p. 2293 - 2295 (2015)
A method for the C-selective alkylation of 2-methylcyclohexane-1,3-dione with unactivated sp3 electrophiles is accomplished via alkylation and subsequent deprotection of the derived ketodimethyl hydrazones. The present method provides a high-yielding entry to dialkyl cycloalkanones that cannot be accessed via direct alkylation of 2-methylcyclohexane-1,3-dione. The title reaction may be useful in the scalable preparation of terpene and steroidal building blocks in the arena of natural product synthesis.
A RE-EXAMINATION OF THE ACID-CATALYSED REACTION OF KETALS WITH 1,2-BIS(TRIMETHYLSILOXY)CYCLOPENTENE
Wu, Yong-Jin,Burnell, D. Jean
, p. 1021 - 1024 (2007/10/02)
Ketals react with 1,2-bis(trimethylsiloxy)cyclopentene in the presence of a large excess of boron trifluoride etherate to provide 2,2-disubstituted 1,3-cyclohexanediones in very good yields.
