123135-90-0

Basic information

• Product Name: C₃₇H₄₆N₂O₂P₂
• CAS NO: 123135-90-0
• Molecular Weight: 612.732
• Mol File: 123135-90-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: C₃₇H₄₆N₂O₂P₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₃₇H₄₆N₂O₂P₂(123135-90-0)
• EPA Substance Registry System: C₃₇H₄₆N₂O₂P₂(123135-90-0)

Safety Data

• Hazardous Substances Data: 123135-90-0(Hazardous Substances Data)

Upstream product

• 123135-92-2 Toluene-4-sulfonic acid (4S,5R)-5-[(di-m-tolyl-phosphanyl)-methyl]-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl ester 
• 123135-91-1 C₁₆H₂₀N₂P^(1-)*Li⁽¹⁺⁾ 
• 37002-45-2 (4S,5S)-2,2-dimethyl-4,5-bis(p-toluenesulfonyloxymethyl)-1,3-dioxolan 
• 1769-51-3 bis-(4-dimethylaminophenyl)phosphine 

Relevant articles and documents

Synthesis of efficient chiral bisphosphine ligands, modified DIOPs, (4R,5R)-4-(Diaryl- or dialkylphosphino)methyl-5-(diarylphosphino)methyl-2,2- dimethyl-1,3-dioxolanes, and their use in rhodium(I)-catalyzed asymmetric hydrogenations

Modified DIOPs, (4R,5R)-4-(diaryl- or dialkyphosphino)methyl-5- (diarylphosphino)methyl-2,2-dimethyl-1,3-dioxolanes, were prepared on the basis of our design concept, and used as ligands for the rhodium(I)-catalyzed asymmetric hydrogenations of ketopantolactone, itaconic acid, dimethyl itaconate, and β-aryl-substituted itaconic acid derivatives. A neutral rhodium(I)-complex of (4R-trans)-dicyclohexyl[[5- [(diphenylphosphino)methyl]-2,2-dimethyl-1,3-dioxolan-4-yl]methyl]phosphine (DIOCP) bearing both a dicyclohexylphosphino group and a diphenylphosphino group was found to be a more efficient catalyst than the original DIOP in the asymmetric hydrogenation of ketopantolactone. Modified DIOPs bearing electron-donating groups at their para positions were efficient ligands for the rhodium(I)-catalyzed assymetric hydrogenations of itaconic acid and its derivatives; in particular, (4R-trans)-[(2,2-dimethyl-1,3-dioxolane-4,5- diyl)bis(methylene)]bis[bis(4'-methoxy-3',5'-dimethylphenyl)phosphine] (MOD- DIOP) bearing both a p-methoxy group and two m,m'-methyl groups on each phenyl group showed much higher enantioselectivity and catalytic activity than DIOP.