123155-05-5

Usage

Uses

Used in Pharmaceutical Industry:
Heptakis(2,3-diMethyl)-β-cyclodextrin is used as a solubility enhancer for poorly water-soluble drugs, improving their bioavailability and pharmacological efficacy. Its ability to form inclusion complexes with drug molecules helps in stabilizing them and enhancing their solubility in aqueous media.
Used in Food Industry:
Heptakis(2,3-diMethyl)-β-cyclodextrin is used as a flavor and odor modifier, helping to mask undesirable tastes and smells in the food products. It can also be used to encapsulate and protect sensitive ingredients, such as vitamins and antioxidants, from degradation.
Used in Cosmetics Industry:
Heptakis(2,3-diMethyl)-β-cyclodextrin is used as a stabilizing and complexing agent in the formulation of cosmetics, particularly in creams, lotions, and perfumes. It helps to improve the solubility and stability of active ingredients, as well as to control the release of fragrances.
Used in Environmental Applications:
Heptakis(2,3-diMethyl)-β-cyclodextrin is used as a chelating agent for the removal of heavy metal ions and other pollutants from water and soil. Its ability to form complexes with various metal ions makes it a promising candidate for environmental remediation.
Used in Research and Analytical Chemistry:
Heptakis(2,3-diMethyl)-β-cyclodextrin is used as a chiral selector in capillary electrophoresis and other analytical techniques, enabling the separation and analysis of enantiomers and other chiral compounds.
Used in Cholesterol Reduction:
Heptakis(2,3-diMethyl)-β-cyclodextrin is used as a cholesterol remover, helping to reduce the toxicity of cholesterol in cells. Its ability to form complexes with cholesterol molecules allows it to effectively lower the cholesterol levels in various biological systems.

Upstream product

• 123155-04-4 heptakis(6-O-tert-butyldimethylsilyl-2,3-di-O-methyl)cyclomaltoheptaose 

Downstream Products

• 166305-90-4 heptakis(2,3-di-O-methyl)-6^I-O-p-tolylsulfonyl-cyclomaltoheptaose 

Relevant academic research and scientific papers

First per-6- o -tritylation of cyclodextrins

Because of the large dimension of the trityl group and the truncated conical geometry of cyclodextrin (CD) molecules, it is unclear if there is enough space at the narrower end of CDs to permit a per-6-O-tritylation. This work demonstrates that it is inde

β-Cyclodextrins modified by alkyl and poly(ethylene oxide) chains: A novel class of mass transfer additives for aqueous organometallic catalysis

A novel class of β-cyclodextrins (β-CDs) bearing alkyl chains on the secondary face and poly(ethylene oxide) chains on the primary face was synthesized. Their interactions with two water-soluble derivatives of triphenylphosphane were investigated by 31P{1H} and 1H NMR. Their behaviour in rhodium-catalysed biphasic hydroformylation of 1-decene was evaluated and the best result was obtained with a β-CD bearing methyl groups on the secondary face and poly(ethylene oxide) chains on the primary face. This CD appeared to be more efficient than randomly methylated β-CD which is currently one of the best mass transfer additives for hydroformylation.

NMR spectroscopy: A powerful tool for detecting the conformational features of symmetrical persubstituted mixed cyclomaltoheptaoses (β-cyclodextrins)

The conformation in solution of exhaustively derivatized mixed cyclomaltooligosaccharides (cyclodextrins) has been defined by NMR spectroscopy. Both tilting of glucopyranose units about the glycosidic linkages and ring deviations from the 4Csu

Synthesis of 6I-amino-6I-deoxy-2I-VII,3I-VII-tetradeca-O-methyl-cyclomaltoheptaose.

The preparation of 6(I)-amino-6(I)-deoxy-2(I-VII),3(I-VII)-tetradeca-O-methyl-cyclomaltoheptaose is reported. Two different routes (A and B), both starting from beta-cyclodextrin (betaCD), have been examined. Route A involved: (i) synthesis of heptakis(6-

Controlled orientation of cyclodextrin derivatives immobilized on gold surfaces

Several different cyclodextrinthiol derivatives have been immobilized on gold surfaces through a chemisorption process to form films which exhibit significantly different features. Three monothiolated cyclodextrin derivatives with different spacers between the cyclodextrin cavity and the thiol group and a mixture of multithiolated cyclodextrin were synthesized and characterized. Chemisorption of these compounds onto gold surfaces gave films which were investigated by Fourier transform infrared (FTIR) spectroscopy, time-of-flight mass spectrometry, contact angle measurements, plasmon surface polariton (PSP) spectroscopy, and cyclic voltammetry. It was found that the chemical structure of each cyclodextrin derivative had a strong influence on the molecular architecture n the resulting films, and in particular on the orientation of the cyclodextrin torus. Models were developed to describe the molecular arrangement in the filmsSeveral different cyclodextrinthiol derivatives have been immobilized on gold surfaces through a chemisorption process to form films which exhibit significantly different features. Three monothiolated cyclodextrin derivatives with different spacers between the cyclodextrin cavity and the thiol group and a mixture of multithiolated cyclodextrins were synthesized and characterized. Chemisorption of these compounds onto gold surfaces gave films which were investigated by Fourier transform infrared (FTIR) spectroscopy, time-of-flight mass spectrometry, contact angle measurements, plasmon surface polariton (PSP) spectroscopy, and cyclic voltammetry. It was found that the chemical structure of each cyclodextrin derivative had a strong influence on the molecular architecture in the resulting films, and in particular on the orientation of the cyclodextrin toms. Models were developed to describe the molecular arrangement in the films.

Novel Cyclodextrin-Oligosiloxane Copolymers for Use as Stationary Phases to Separate Enantiomers in Open Tubular Column Supercritical Fluid Chromatography

Five novel β- (or α-) cyclodextrin-hexasiloxane copolymers have been prepared by a seven- (or nine-) step process.A key step was the reaction of partially alkylated β- (or α-) cyclodextrin (8, 9, or 10) with p,p'-methylenebis(benzenesulfonyl chloride) to

Selective chemical modification of cyclomalto-oligosaccharides via tert-butyldimethylsilylation

Selective reaction of cyclomaltoheptaose and cyclomalto-octaose with tert-butylchlorodimethylsilane in N,N-dimethylformamide in the presence of inidazole gave the heptakis(6-O-tert-butyldimethylsilyl) (21) and octakis(6-O-tert-butyldimethylsilyl) (27) der