123159-98-8Relevant academic research and scientific papers
LIMITATIONS IN THE APPLICATION OF ANIONIC OXY-COPE SIGMATROPY TO ELABORATION OF THE FORSKOLIN NUCLEUS
Paquette, Leo A.,Oplinger, Jeffrey A.
, p. 107 - 124 (2007/10/02)
The functionalized bicyclooctenone 6 has been synthesized in four steps from 2,4,4-trimethyl-2-cyclohexenone.This ketone undergoes 1,2-addition with 6-lithiodihydropyran to deliver alcohols 16 and 17 in a 1:1.8 ratio.The potassium salt of 17 experi
SYNTHESIS OF THE FORSKOLIN SKELETON VIA ANIONIC OXY-COPE REARRANGEMENT
Oplinger, Jeffrey A.,Paquette, Leo A.
, p. 5441 - 5444 (2007/10/02)
The forskolin prototype 14 has been elaborated in 9 steps from 2,4,4-trimethyl-cyclohexenone (5), the entire ring system materializing during oxyanionic Cope rearrangement of alcohol 10.
