123169-65-3Relevant academic research and scientific papers
Enantioselective Copper-Catalyzed Radical Ring-Opening Cyanation of Cyclopropanols and Cyclopropanone Acetals
Chen, Pinghong,Guo, Yin-Long,Liu, Guosheng,Wang, Lei,Wu, Lianqian
, p. 2189 - 2194 (2020/04/17)
A novel approach for enantioselective cyanation of cyclopropanols and their derivatives through copper-catalyzed radical relay processes has been developed. Various cyclopropanols and cyclopropanone acetals are compatible to the catalytic conditions, providing β-carbonyl nitriles with excellent enantioselectivity. These products can be readily converted to chiral γ-amino acids derivatives and drugs such as (R)-baclofen. Preliminary mechanistic studies have supported a ring-opening process for cyclopropanoxy radicals followed by copper-catalyzed enantioselective cyanation of benzylic radicals to form the C?CN bonds in an enantioselective manner. (Figure presented.).
AN IMPROVED SYNTHESIS OF SUBSTITUTED CYCLOPROPANONE ACETALS AND HEMIACETALS
Rousseau, G.,Slougui, N.
, p. 1251 - 1254 (2007/10/02)
Cyclopropanation of ketene alkylsilylacetals or ketene disilylacetals with diethylzinc-methylene iodide leads to cyclopropanone acetals in high yield, and after methanolysis to cyclopropanone hemiacetals or hydrates.
