1231733-75-7Relevant academic research and scientific papers
Design, synthesis, and biological evaluation of a novel class of γ-secretase modulators with pparγ activity
Hieke, Martina,Ness, Julia,Steri, Ramona,Dittrich, Michaela,Greiner, Christine,Werz, Oliver,Baumann, Karlheinz,Schubert-Zsilavecz, Manfred,Weggen, Sascha,Zettl, Heiko
supporting information; experimental part, p. 4691 - 4700 (2010/10/03)
We present a novel class of dual modulators of γ-secretase and peroxisome proliferator-activated receptor γ (PPARγ) based on the structure of 2-(bis(phenethoxy)pyrimidine-2-ylthio)hexanoic acid 8 (IC 50(Aβ42) = 22.8 μM, EC50(PPARγ) =
