1231819-50-3

Basic information

• Product Name: (4-Hydroxyphenyl)[4-[2-(MethylaMino)ethoxy]phenyl]Methanone
• Synonyms: (4-Hydroxyphenyl)[4-[2-(MethylaMino)ethoxy]phenyl]Methanone
• CAS NO: 1231819-50-3
• Molecular Formula: C₁₆H₁₇NO₃
• Molecular Weight: 271.31108
• Product Categories: Amines;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals;Amines, Aromatics, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 1231819-50-3.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (4-Hydroxyphenyl)[4-[2-(MethylaMino)ethoxy]phenyl]Methanone(CAS DataBase Reference)
• NIST Chemistry Reference: (4-Hydroxyphenyl)[4-[2-(MethylaMino)ethoxy]phenyl]Methanone(1231819-50-3)
• EPA Substance Registry System: (4-Hydroxyphenyl)[4-[2-(MethylaMino)ethoxy]phenyl]Methanone(1231819-50-3)

Safety Data

• Hazardous Substances Data: 1231819-50-3(Hazardous Substances Data)

Usage

Uses

(4-Hydroxyphenyl)[4-[2-(MethylaMino)ethoxy]phenyl]Methanone can be used in the preparation of heterocycles as estrogen receptor modulators.

Upstream product

• 1215295-57-0 (4-(2-chloroethoxy)phenyl)(4-hydroxyphenyl)methanone 
• 74-89-5 methylamine 
• 100-07-2 4-methoxy-benzoyl chloride 
• 13380-49-9 (4-(2-chloroethoxy)phenyl)(4-methoxyphenyl)methanone 
• 622-86-6 2-chloroethoxybenzene 
• 173163-13-8 4-<2-(N,N-dimethylamino)ethoxy>-4'-hydroxybenzophenone 

Downstream Products

• 114828-90-9 trans-Endoxifen 

Relevant articles and documents

TOPICAL COMPOSITIONS AND METHODS FOR TREATMENT

The present disclosure provides novel topical compositions comprising endoxifen and salts and solvates thereof and methods for making the compositions. Certain compounds have been combined to make a stable topical compositions comprising endoxifen. The pr

A convenient synthesis of (Z)-4-hydroxy-N-desmethyltamoxifen (endoxifen)

A mixture of the (Z)- and (E)-isomers of 4-hydroxy-N-desmethyltamoxifen was conveniently prepared in four steps. These geometrical isomers were then neatly separated by semi-preparative Reverse Phase High Performance Liquid Chromatography (RP-HPLC) using specified conditions. Additionally, the isolated E-isomer could be equilibrated in aqueous strong acid in acetonitrile or trifluoroacetic acid/dichloromethane to give a clean 1:1 mixture of Z/E isomers that was re-subjected to HPLC separation. In this way, most of the undesired (E)-isomer could be readily converted to the desired (Z)-isomer providing quick access to over 200 mg quantities of pure endoxifen (Z-isomer), a potent antiestrogenic metabolite of tamoxifen traditionally used in breast cancer treatment.