123185-91-1

Downstream Products

• 118918-05-1 trans-(4R,6S)-6-[4,4-bis(4-fluorophenyl)-3-(1-methyl-1H-tetrazol-5-yl)-1,3-butadienyl]-tetrahydro-4-hydroxy-2H-pyran-2-one 
• 118845-89-9 cis-(4R,6S)-6-<4,4-bis(4-fluorophenyl)-3-(1-methyl-1H-tetrazol-5-yl)-1,3-butadienyl>-2,2-dimethyl-1,3-dioxane-4-acetic acid 
• 129785-03-1 (E)-(3R,5S)-9,9-Bis-(4-fluoro-phenyl)-3,5-dihydroxy-8-(1-methyl-1H-tetrazol-5-yl)-nona-6,8-dienoic acid 
• 130320-56-8 BMY-21950 

Relevant academic research and scientific papers

Antihypercholesterolemic tetrazole compounds

Compounds of the formula STR1 wherein R1 and R4 each are independently hydrogen, halogen, C1-4 alkyl, C1-4 alkoxy, or trifluoromethyl; R2, R3, R5 and R6 each are independently hydrogen, halogen C1-4 alkyl or C1-4 alkoxy; tet is STR2 n is an integer of from 0 to 2, inclusive; A is STR3 R7 is hydrogen, C1-4 alkyl, C1-4 alkoxy(lower) alkyl or (2-methoxyethoxy)methyl; X is --OH or =O; and R8 is hydrogen, a hydrolyzable ester group or a cation to form a non-toxic pharmaceutically acceptable salt, are novel antihypercholesterolemic agents which inhibit cholesterol biosynthesis. Intermediates and processes for their preparation are disclosed.

Intermediates for antihypercholesterolemic tetrazole compounds

This invention provides novel intermediates of the formula STR1 in substantially the cis or cis-(4R,6S) form wherein R9 and R10 each are C1-4 alkyl or R9 and R10, taken together with the carbon atom to which they are attached, is cyclopentyl, cyclohexyl or cycloheptyl; and R12 is hydrogen, C1-4 alkyl or a metal cation and processes thereof which are useful for the preparation of antihypercholesterolemic agents.

Antihypercholesterolemic tetrazol-1-yl compounds

Compounds of the formula STR1 wherein R1, R2, R3, and R4 each are independently hydrogen, halogen, C1-4 alkyl, C1-4 alkoxy or trifluoromethyl; R is hydrogen, C1-4 alkyl or phenyl; A is STR2 R5 is hydrogen, a hydrolyzable ester group or a cation to form a non-toxic pharmaceutically acceptable salt, are novel antihypercholesterolemic agents which inhibit cholesterol biosynethesis. Intermediates and processes for their preparation are disclosed.