1231890-91-7

Basic information

• Product Name: 2-(3-Bromo-2-methylphenyl)-5-(tert-butyl)isoindoline-1,3-dione
• Synonyms: 2-(3-Bromo-2-methylphenyl)-5-(tert-butyl)isoindoline-1,3-dione
• CAS NO: 1231890-91-7
• Molecular Weight: 372.261
• Mol File: 1231890-91-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-(3-Bromo-2-methylphenyl)-5-(tert-butyl)isoindoline-1,3-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3-Bromo-2-methylphenyl)-5-(tert-butyl)isoindoline-1,3-dione(1231890-91-7)
• EPA Substance Registry System: 2-(3-Bromo-2-methylphenyl)-5-(tert-butyl)isoindoline-1,3-dione(1231890-91-7)

Safety Data

• Hazardous Substances Data: 1231890-91-7(Hazardous Substances Data)

Upstream product

• 32703-79-0 4-tert-butylphthalic anhydride 
• 55289-36-6 3-bromo-2-methylaniline 

Downstream Products

• 1231890-99-5 2-(3-bromo-2-methylphenyl)-6-tert-butylisoindolin-1-one 
• 1231891-00-1 2-(3-bromo-2-methylphenyl)-5-(tert-butyl)isoindolin-1-one 

Relevant articles and documents

Design, synthesis and evaluation of novel 5-phenylpyridin-2(1H)-one derivatives as potent reversible Bruton's tyrosine kinase inhibitors

A series of novel reversible Btk inhibitors has been designed based on the structure of the recently reported preclinical drug RN486. The synthesis and SAR of these compounds are described. Among these derivatives, compound 16b was identified to be a potent and orally available reversible agent with satisfactory Btk enzymatic and cellular inhibition in vitro, as well as favorable PK properties and inhibition of arthritis in vivo.

CARBAZOLE CARBOXAMIDE COMPOUNDS USEFUL AS KINASE INHIBITORS

Compounds having the formula (I), and enantiomers, and diastereomers, pharmaceutically-acceptable salts, thereof, are useful as kinase modulators, including Btk modulation.