123193-99-7

Basic information

• Product Name: 1-AMINOCYCLOHEPTANECARBONITRILE
• Synonyms: 1-AMINOCYCLOHEPTANECARBONITRILE;1-Amino-1-cycloheptanecarbonitrile;1-aminocycloheptanecarbonitrile hydrochloride
• CAS NO: 123193-99-7
• Molecular Formula: C₈H₁₄N₂
• Molecular Weight: 138.21016
• Mol File: 123193-99-7.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 80 °C(Press: 0.6 Torr)
• Appearance: /
• Density: 0.98±0.1 g/cm3(Predicted)
• PKA: 5.18±0.20(Predicted)
• CAS DataBase Reference: 1-AMINOCYCLOHEPTANECARBONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-AMINOCYCLOHEPTANECARBONITRILE(123193-99-7)
• EPA Substance Registry System: 1-AMINOCYCLOHEPTANECARBONITRILE(123193-99-7)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 123193-99-7(Hazardous Substances Data)

Usage

General Description

1-Aminocycloheptanecarbonitrile is a chemical compound with the molecular formula C8H13N. It is a bicyclic amino compound with a seven-membered ring structure and a nitrile functional group. 1-AMINOCYCLOHEPTANECARBONITRILE is commonly used as a building block in organic synthesis and pharmaceutical research, where it is utilized for the production of various drugs and pharmaceutical products. It is also used in the development of new materials and in chemical research as a precursor for the synthesis of other complex organic molecules. Additionally, 1-Aminocycloheptanecarbonitrile is known for its potential biological activity and may have applications in the development of new drugs and pharmaceuticals in the future.

Upstream product

• 502-42-1 cycloheptanone 
• 773837-37-9 sodium cyanide 
• 143-33-9 sodium cyanide 

Downstream Products

• 5062-68-0 1-Amino-1-aminomethyl-cycloheptan 
• 183429-63-2 C₉H₁₇NO₂ 
• 814254-62-1 (1-aminocycloheptyl)methanol 
• 6949-77-5 1-aminocycloheptane-1-carboxylic acid 
• 906075-26-1 1-aminocycloheptanecarboxamide 

Relevant articles and documents

Studies on phosphoroheterocycle chemistry II: A simple and new route to 1,3,2-diazaphospholidine-4-thione 2-sulfide derivatives

A simple and new method for the synthesis of phosphoroheterocycles 1,3,2-diazaphospholidine-4-thione 2-sulfide derivatives by treatment of Lawesson's reagent (LR) with a variety of α-aminonitriles has been developed. The same methodology was also used in the preparation of fused phosphoroheterocycle 6 from 5-amino-4-cyano-3-methylthia-l-phenylpyrazole. The possible mechanism of the reaction involving addition of P-SH to the nitrile and subsequent rearrangement is proposed.

Photoreactive fused aziridinylpiperazines on the background of 4-substituted chalcones and their benzimidazolic analogs

The reaction of bromo-substituted chalcones with various diamino-compounds leads to the fused heterocyclic products, aziridinylpiperazines, exhibiting photoreactivity in the crystalline state. Crystals of 4-nitrosubstituted compounds of this family change their color from yellowish to deep violet-blue, 4-cyanosubstituted ones – from yellowish to pink at UV irradiation. Discussion on the mechanism of this phototransformation is still in progress, however, several facts points to the free radial nature of the photogenerated colored semi-products stabilized only by crystalline state of the irradiated samples. Formation of a mixture of positional isomers at interaction of bromo-chalcones with asymmetric diamines of aliphatic/alicyclic or aromatic series at synthesis of the title compounds is of significant interest as well.

Design and synthesis of certain substituted cycloalkanecarboxamides structurally related to safinamide with anticonvulsant potential

A series of novel safinamide derivatives were synthesized and biologically evaluated for their anticonvulsant activity against maximal electroshock seizure assay and subcutaneous pentylenetetrazole (s.c. PTZ) screening test. Compound 13b is the most active derivative in s.c. PTZ screening test with an ED50 value lower than that of safinamide by about tenfold. A molecular modeling study, including fitting to sodium channel blockers 3D-pharmacophore model and docking into a branched-chain aminotransferase enzyme active site were consistent with the in vivo results.