1231930-33-8

Basic information

• Product Name: 6-Bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole
• Synonyms: 6-Bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole;6-Bromo-4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazole;1H-BenziMidazole, 6-broMo-4-fluoro-2-Methyl-1-(1-Methylethyl)-;6-bromo-4-fluoro-2-methyl-1-propan-2-ylbenzimidazole
• CAS NO: 1231930-33-8
• Molecular Formula: C₁₁H₁₂BrFN₂
• Molecular Weight: 271
• Mol File: 1231930-33-8.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 353.4±22.0 °C(Predicted)
• Appearance: /
• Density: 1.49
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 3.48±0.10(Predicted)
• CAS DataBase Reference: 6-Bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole(1231930-33-8)
• EPA Substance Registry System: 6-Bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole(1231930-33-8)

Safety Data

• Hazardous Substances Data: 1231930-33-8(Hazardous Substances Data)

Usage

Flammability and Explosibility

Notclassified

Upstream product

• 1301214-70-9 2-methyl-4-fluoro-6-bromo-1H-benzo[d]imidazole 
• 67-64-1 acetone 
• 42717-36-2 N-isopropylethanimidamide 
• 67567-26-4 4-bromo-2,6-difluoroaniline 
• 1118-69-0 N-isopropylacetamide 
• 1231930-29-2 N-(4-bromo-2,6-difluorophenyl)-N'-isopropylacetamidine 

Downstream Products

• 1231930-37-2 4-fluoro-1-isopropyl-2-methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolane-2-yl)-1H-benzo[d]imidazole 
• 1231929-97-7 N-(5-((4-ethyl-1-piperazinyl)methyl)-2-pyridinyl)-5-fluoro-4-(4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazol-6-yl)-2-pyrimidinamine 
• 1231930-42-9 6-(2-chloro-5-fluoropyrimidin-4-yl)-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole 
• 1231930-82-7 abemaciclib 
• 1231930-82-7 LY2835219 

Relevant articles and documents

A 2-aminopyrimidine heterocyclic compound and its applications

The present invention discloses a 2-aminopyrimidine heterocyclic compound having a general formula I structure and its applications, which are kinase CDK4, CDK6 and / or CDK9 inhibitors, can be more widely used in the treatment of a variety of cancers, ha

A pyrimidine compound and its application

The present invention discloses a pyrimidine amine compound having a general formula I structure and its applications, the class of compounds belongs to the kinase CDK4, CDK6 and / or CDK9 inhibitors, can be more widely used in the treatment of a variety

Synthesis method of 6-bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[D]imidazole

The invention discloses a synthesis method of 6-bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[D]imidazole. The method comprises the following steps: (1) adding sodium hydride into a reaction bottle, adding an aprotic solvent into the reaction bottle, and carrying out a constant-temperature stirring reaction; (2) dissolving N-(4-bromo-2,6-difluorophenyl)-N'-isopropylacetamidine in the aprotic solvent, slowly dropwise adding the clarified solution into a reaction bottle, heating the reaction system to 40-100 DEG C, and then carrying out a stirring reaction for 4-10 h; (3) cooling to room temperature after the reaction is completed, adding water to prepare a solution, extracting for three times, mixing organic phases, washing the organic phase with a saturated saline solution once, drying withanhydrous sodium sulfate, and filtering; and (4) concentrating the obtained filtrate, adding n-hexane for dissolving, adding deionized water into the reaction system solution, standing overnight, andfiltering and drying after white crystals are separated out to obtain the 6-bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[D]imidazole. The synthesis method is short in reaction time and simple in treatment, the labor cost is saved, and the environmental pollution is reduced.