123194-01-4 Usage
Bicyclic amine
Azabicyclo[2.2.2]octane
Explanation
This term describes the structure of the compound, which consists of two interconnected rings and an amine (NH2) group.
Explanation
A carbonitrile group is a functional group consisting of a carbon atom triple-bonded to a nitrogen atom (C≡N). In this compound, it is attached to the third carbon atom of the bicyclic structure.
Explanation
The compound is used as a starting material or intermediate in the synthesis of various pharmaceuticals and agrochemicals, which are chemicals used in the medical and agricultural industries, respectively.
Explanation
Due to its unique structure and reactivity, the compound may have potential uses in the fields of organic synthesis (the formation of carbon-containing compounds) and medicinal chemistry (the design and development of pharmaceuticals).
6. Hazardous if not properly managed
Explanation
The compound can pose risks to human health and the environment if not handled with care. Proper safety measures, such as wearing protective gear and following safety protocols, should be taken when working with this chemical.
Explanation
The compound's unique structure and properties make it a valuable asset in various fields, including chemistry and pharmaceuticals, due to its potential for use in a wide range of applications.
Carbonitrile group
CN
Intermediate in synthesis
Pharmaceutical and agrochemicals
Potential applications
Organic synthesis and medicinal chemistry
Versatile compound
Wide range of potential uses
Check Digit Verification of cas no
The CAS Registry Mumber 123194-01-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,3,1,9 and 4 respectively; the second part has 2 digits, 0 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 123194-01:
(8*1)+(7*2)+(6*3)+(5*1)+(4*9)+(3*4)+(2*0)+(1*1)=94
94 % 10 = 4
So 123194-01-4 is a valid CAS Registry Number.
123194-01-4Relevant articles and documents
NOVEL SPIRO-QUINUCLIDINYL DERIVATIVES FOR THE TREATMENT OF THE CENTRAL NERVOUS SYSTEM DISORDERS
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Page/Page column 36-37, (2008/12/06)
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Novel spiro-quinuclidinyl derivatives for the treatment of central nervous system disorders
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Page/Page column 13, (2010/11/25)
The present invention is directed to novel spiro-quinuclidinyl derivatives, pharmaceutical compositions containing them and their use in the treatment of central nervous system disorders.
(-)-Spiro[1-azabicyclo[2.2.2]octane-3,5'-oxazolidin-2-one], a Conformationally restricted analogue of acetylcholine, is a highly selective full agonist at the α7 nicotinic acetylcholine receptor
Mullen,Napier,Balestra,Decory,Hale,Macor,Mack,Loch III,Wu,Kover,Verhoest,Sampognaro,Phillips,Zhu,Murray,Griffith,Blosser,Gurley,Machulskis,Zongrone,Rosen,Gordon
, p. 4045 - 4050 (2007/10/03)
Neuronal nicotinic acetylcholine receptors are members of the ligand-gated ion channel receptor superfamily and may play important roles in modulating neurotransmission, cognition, sensory gating, and anxiety. Because of its distribution and abundance in the CNS, the α7 nicotinic receptor is a strong candidate to be involved in some of these functions. In this paper we describe the synthesis and in vitro profile of AR-R17779, (-)-spiro[1-azabicyclo[2.2.2]octane-3,5'oxazolidin-2'-one] (4a), a potent full agonist at the rat α7 nicotinic receptor, which is highly selective for the rat α7 nicotinic receptor over the α4β2 subtype. Preliminary SAR of AR-R17779 presented here indicate that there is little scope for modification of this rigid molecule as even minor changes result in significant loss of the α7 nicotinic receptor affinity.
