1231950-82-5

Basic information

• Product Name: 2-Isopropyl-5,6-dihydro-1H-benzo[d]iMidazol-7(4H)-one
• Synonyms: 2-Isopropyl-5,6-dihydro-1H-benzo[d]iMidazol-7(4H)-one
• CAS NO: 1231950-82-5
• Molecular Formula: C10H14N2O
• Molecular Weight: 178.23096
• Mol File: 1231950-82-5.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 396.2±11.0 °C(Predicted)
• Appearance: /
• Density: 1.154±0.06 g/cm3(Predicted)
• PKA: 11.21±0.20(Predicted)
• CAS DataBase Reference: 2-Isopropyl-5,6-dihydro-1H-benzo[d]iMidazol-7(4H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Isopropyl-5,6-dihydro-1H-benzo[d]iMidazol-7(4H)-one(1231950-82-5)
• EPA Substance Registry System: 2-Isopropyl-5,6-dihydro-1H-benzo[d]iMidazol-7(4H)-one(1231950-82-5)

Safety Data

• Hazardous Substances Data: 1231950-82-5(Hazardous Substances Data)

Upstream product

• 85493-96-5 2-bromo-3-methoxy-2-cyclohexenone 

Downstream Products

• 1231951-03-3 3-[(3,4-dichlorophenyl)methyl]-2-(1-methylethyl)-3,5,6,7-tetrahydro-4H-benzimidazol-4-one 
• 1231951-11-3 3-[(3-iodophenyl)methyl]-2-(1-methylethyl)-3,5,6,7-tetrahydro-4H-benzimidazol-4-one 
• 1231950-83-6 3-[(4-chlorophenyl)methyl]-2-(1-methylethyl)-3,5,6,7-tetrahydro-4H-benzimidazol-4-one 
• 1231951-08-8 3-[(4-iodophenyl)methyl]-2-(1-methylethyl)-3,5,6,7-tetrahydro-4H-benzimidazol-4-one 

Relevant articles and documents

N-(1-(METHYLSULFONYL)PIPERIDIN-4-YL)-4,5-DI HYDRO-1H-IMIDAZO[4,5-H]QUINAZOLIN-8-AMINE DERIVATIVES AND RELATED COMPOUNDS AS CYCLIN-DEPENDENT KINASE 2 (CDK2) INHIBITORS FOR TREATING CANCER

The present application provid es tricyclic amine compounds of formula (I) as inhibitors of cyclin-dependent kinase 2 (CDK2) for treating cancer. Preferred compounds are N-(1-(methylsulfonyl)piperidin-4- yl)-4,5-dihydro-lH-imidazo[4,5-h]quinazolin-8-amine and the corresponding 6,8-dihydro-5H-pyrazolo[3,4-h]quinazolin-2-amine, 6,8- dihydropyrazolo[4',3':4,5]pyrano[3,2-d]pyrimidin-2-amine and 1,4- dihydroimidazo[4',5': 4,5]pyrano[3,2-d]pyrimidin-8-amine derivatives of formulae (IVa) to (IVd). The present description discloses the synthesis and characterisation of exemplary compounds as well as pharmacological data thereof (e.g. pages 128 to 166; examples 1 to 32, A and B1 to B10; table 1). Exemplary compound are e.g.: N-(1-(ethylsulfonyl)piperidin-4-yl)-l,2-dimethyl-4,5-dihydro-1H- imidazo[4,5-h]quinazolin-8-amine (example 1) 8-Methyl-N-(1-(methylsulfonyl)piperidin-4-yl)-6,8-dihydro-5H- pyrazolo[3,4-h]quinazolin-2-amine (example 9) 8-Methyl-N-(1-(methylsulfonyl)piperidin-4-yl)-6,8- dihydropyrazolo[4',3':4,5]pyrano[3,2-d]pyrimidin-2-amine (example 10) 1-cyclopropyl-N-(1-(methylsulfonyl)piperidin-4-yl)-l,4- dihydroimidazo[4',5':4,5]pyrano [3,2-d]pyrimidin-8-amine (example 26).