123199-96-2Relevant articles and documents
Asymmetric total synthesis of dihydroisocoumarins: 6-methoxymellein, kigelin and fusarentin 6, 7 dimethyl ether by employing proline catalysed asymmetric α-aminoxylation
Mane, Baliram B.,Markad, Sachin B.,Waghmode, Suresh B.
, (2020/10/19)
A concise asymmetric total synthesis of dihydroisocoumarins such as 6-methoxymellein, kigelin and fusarentin 6,7-dimethyl ether in high enantiopurity have been achieved from non-chiral aldehydes by employing proline catalysed asymmetric α-aminoxylation reaction. The required stereochemistry of hydroxyl group have been generated by alternating L or D proline as a organocatalyst in α-aminoxylation step and lactone ring is assembled by oxa-Pictet-Spengler cyclisation reaction as the key steps.
First enantioselective synthesis of the neolignans Rhaphidecursinol A and Virolongin B
Ren, Xinfeng,She, Xuegong,Peng, Kun,Su, Ying,Xie, Xingang,Pan, Xinfu,Zhang, Hongbin
, p. 969 - 974 (2007/10/03)
The enantioselective synthesis of the neolignans Rhaphidecursinol A and Virolongin B is reported for the first time. The key reactions in the synthesis were Sharpless asymmetric dihydroxylation and Mitsunobu reaction. The absolute configuration of Rhaphidecursinol A was confirmed.
