123206-13-3

Upstream product

• 123206-12-2 (2RS,3RS)-2-hydroxy-4-phenyl-3-(phenylcarbonyl)amino-1,1,1-trifluorobutane 
• 6125-24-2 2-Phenylnitroethane 
• 102195-92-6 3-nitro-4-phenyl-1,1,1-trifluorobutan-2-ol 

Downstream Products

• 102196-01-0 (S)-2-Acetylamino-4-methyl-pentanoic acid (1-benzyl-3,3,3-trifluoro-2-hydroxy-propyl)-amide 
• 189167-73-5 (S)-2-Acetylamino-4-methyl-pentanoic acid (1-benzyl-3,3,3-trifluoro-2-oxo-propyl)-amide 
• 124044-50-4 Boc-Ala-Val-Phe-CH(OH)CF₃ 

Relevant academic research and scientific papers

THIAZOLIDINE DERIVATIVES

An object of the present invention is to provide novel thiazolidine derivatives which are useful as drugs. The thiazolidine derivatives according to the present invention are compounds represented by the following general formula [I] and salts thereof, wherein R 1is alkyl, hydroxy, alkoxy, alkoxyalkyl, phenyl, phenylalkyl, phenylalkoxy, phenoxy, phenoxyalkyl, amino, alkylamino or a nonaromatic heterocycle; R 2is H or alkyl; R 3is H, alkyl or phenyl; R 4is H or alkyl; R 5is alkyl, halogenoalkyl, hydroxy, alkoxy, phenyl, phenylalkoxy, phenoxy, carboxyl, alkoxycarbonyl, phenylalkoxycarbonyl or an aromatic heterocycle; A 1is alkylene; and A 2is alkylene.

A VERSATILE SYNTHESIS OF PEPTIDYL FLUOROMETHYL KETONES

A versatile synthesis of peptidyl fluoromethyl ketones with potential as serine protease inhibitors is described.