1232149-37-9

Upstream product

• 723280-94-2 7-bromo-3-nitroquinolin-4-ol 
• 82121-06-0 4-hydroxy-7-bromoquinoline 
• 1232149-36-8 4-amino-7-bromo-3-nitroquinoline 
• 723280-98-6 7-bromo-4-chloro-3-nitroquinoline 

Downstream Products

• 1355477-88-1 C₁₅H₁₄BrN₃O 
• 1355478-26-0 7-bromo-2-(2-chlorophenyl)imidazo[4,5-c]quinolin-4(5H)-one 
• 1355478-15-7 HCl 
• 1355478-08-8 C₁₇H₉BrF₃N₃ 
• 1355478-06-6 C₂₂H₁₄BrN₃ 
• 1355478-10-2 C₁₇H₉BrN₄ 
• 1232148-45-6 C₁₈H₁₅BrN₄ 
• 1355478-01-1 C₁₇H₁₂BrN₃ 
• 1355477-98-3 C₁₆H₉BrClN₃ 
• 1436688-58-2 2-(2-chloro-6-fluorophenyl)-7-(2-methylphenyl)imidazo[4,5-c]quinolin-4(5H)-one 
• 1436688-61-7 2-(2-chloro-6-fluorophenyl)-7-(3-methylphenyl)imidazo[4,5-c]quinolin-4(5H)-one 
• 1436688-64-0 2-(2-chloro-6-fluorophenyl)-7-(4-methylphenyl)imidazo[4,5-c]quinolin-4(5H)-one 
• 1436688-67-3 2-(2-chloro-6-fluorophenyl)-7-(2-chlorophenyl)imidazo[4,5-c]quinolin-4(5H)-one 
• 1436688-73-1 2-(2-chloro-6-fluorophenyl)-7-(4-chlorophenyl)imidazo[4,5-c]quinolin-4(5H)-one 

Relevant academic research and scientific papers

NLRP3 MODULATORS

The present invention provides compounds of Formula (I), wherein all of the variables are as defined herein. These compounds are modulators of NLRP3, which may be used as medicaments for the treatment of proliferative disorders, such as cancer in a subject (e.g., a human).

Synthesis and SAR study of imidazoquinolines as a novel structural class of microsomal prostaglandin E2 synthase-1 inhibitors

The imidazoquinoline derivative 1 was found as a novel mPGES-1 inhibitor. Optimization of 1 led to the identification of the 2-chlorophenyl group at the C(2)-position and the quinolone structure at the C(4)-position. Compound 33, the most potent synthesized compound, showed excellent mPGES-1 inhibition (IC 50 = 9.1 nM) with high selectivity (>1000-fold) over both COX-1 and COX-2.