123217-81-2Relevant academic research and scientific papers
Synthesis and structure-activity relationships of novel poly(ADP-ribose) polymerase-1 inhibitors
Tao, Ming,Park, Chung Ho,Bihovsky, Ron,Wells, Gregory J.,Husten, Jean,Ator, Mark A.,Hudkins, Robert L.
, p. 938 - 942 (2007/10/03)
A series of novel pyrrolocarbazoles was synthesized as potential PARP-1 inhibitors. Pyrrolocarbazole 1 was identified as a potent PARP-1 inhibitor (IC50 = 36 nM) from our internal database. Synthesis of analogs around this template with the aid
Selective Wittig Reactions for the Synthesis of Variously Substituted 2-Vinylindoles
Eitel, Manfred,Pindur, Ulf
, p. 364 - 367 (2007/10/02)
Three selective variants of the Wittig reaction for the syntheses of 2-vinylindoles are described.The reactions are relatively easy to perform, exhibit E-selectivity, and are characterized by a good flexibility with regard to the functional groups present in the vinyl moiety.
