1232185-60-2Relevant academic research and scientific papers
Structural modifications of CH(OH)-DAPYs as new HIV-1 non-nucleoside reverse transcriptase inhibitors
Yan, Zi-Hong,Huang, Xia-Yun,Wu, Hai-Qiu,Chen, Wen-Xue,He, Qiu-Qin,Chen, Fen-Er,De Clercq, Erik,Pannecouque, Christophe
, p. 2535 - 2541 (2014/05/06)
A series of CR2(OH)-diarylpyrimidine derivatives (CR 2(OH)-DAPYs) featuring a hydrophobic group at CH(OH) linker between wing I and the central pyrimidine were synthesized and evaluated for their anti-HIV activity in MT-4 cell cultur
Synthesis and biological evaluation of CHX-DAPYs as HIV-1 non-nucleoside reverse transcriptase inhibitors
Yan, Zi-Hong,Wu, Hai-Qiu,Chen, Wen-Xue,Wu, Yan,Piao, Hu-Ri,He, Qiu-Qin,Chen, Fen-Er,De Clercq, Erik,Pannecouque, Christophe
, p. 3220 - 3226 (2014/06/09)
A series of new diarylpyrimidines (DAPYs) characterized by a halogen atom on the methylene linker between wing I and the central pyrimidine ring was synthesized and evaluated for their anti-HIV activity in MT-4 cell cultures. The two most promising compou
Design and synthesis of a new series of cyclopropylamino-linking diarylpyrimidines as HIV non-nucleoside reverse transcriptase inhibitors
Liu, Yang,Meng, Ge,Zheng, Aqun,Chen, Fener,Chen, Wenxue,Clercq, Erik De,Pannecouque, Christophe,Balzarini, Jan
, p. 334 - 341 (2014/07/22)
A new series of 29 diarylpyrimidine analogues featuring a cyclopropylamino group between the pyrimidine scaffold and the aryl wing have been synthesized. All of the new compounds have been characterized by spectra analysis. The target molecules were evalu
Synthesis and structure-activity relationship of novel diarylpyrimidines with hydromethyl linker (CH(OH)-DAPYs) as HIV-1 NNRTIs
Gu, Shuang-Xi,He, Qiu-Qin,Yang, Shi-Qiong,Ma, Xiao-Dong,Chen, Fen-Er,Clercq, Erik De,Balzarini, Jan,Pannecouque, Christophe
, p. 5117 - 5124 (2011/10/04)
A series of 26 diarylpyrimidines, characterized by the hydroxymethyl linker between the left wing benzene ring and the central pyrimidine, were synthesized and evaluated for in vitro anti-HIV activity. Most of the compounds exhibited moderate to excellent
Lead optimization of diarylpyrimidines as non-nucleoside inhibitors of HIV-1 reverse transcriptase
Zeng, Zhao-Sen,Liang, Yong-Hong,Feng, Xiao-Qing,Chen, Fen-Er,Pannecouque, Christophe,Balzarini, Jan,De Clercq, Erik
experimental part, p. 837 - 840 (2011/02/24)
Antiviral agents: A series of CN-CH2-DAPY analogues were identified as novel non-nucleoside reverse transcriptase inhibitors (NNRTIs) against HIV-1. Most of the newly synthesized compounds exhibited strong activity against wild-type HIV-1.
