1232206-80-2Relevant academic research and scientific papers
Novel acenaphthopyrazine derivatives as antitumor agents against MCF-7 cells: Molecular synthesis, optical properties, and DNA-binding studies
Xing, Junling,Cui, Jingnan,Wang, Shuang,Gao, Jin,Zhang, Zhichao
, p. 243 - 250 (2012)
A series of novel acenaphthopyrazine derivatives was synthesized from acenaphthylene-1,2-dione via three steps, including bromination, cyclization, and SNArH reaction. These new compounds exhibited potential antiproliferative activity against MCF-7 cells in vitro, and 3-[2-(dimethylamino)ethylamino]acenaphtho[1,2-b]pyra-zine-8,9-dicarbonitrile exhibited the highest activity (IC50 = 4.60 μM). DNA-binding experiments suggested that these derivatives bind to DNA through intercalation with intrinsic binding constants K all above 105 M-1. Optical property studies indicated that these compounds have long emission wavelength (λem > 560 nm), high quantum yields in toluene (Φf = 0.59 for 3-(morpholin-4-yl)acenaphtho[1,2-b]pyrazine-8,9- dicarbonitrile), and large Stokes shift (ΔS > 130 nm).
