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CAS

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123227-12-3

11-<<2-<(2-methoxybenzoyl)amino>ethyl>thio>-6,11-dihydrobenzoxepin-2-carboxylic acid methyl ester is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 123227-12-3 Structure

  • Basic information

    1. Product Name: 11-<<2-<(2-methoxybenzoyl)amino>ethyl>thio>-6,11-dihydrobenzoxepin-2-carboxylic acid methyl ester
    2. Synonyms: 11-<<2-<(2-methoxybenzoyl)amino>ethyl>thio>-6,11-dihydrobenzoxepin-2-carboxylic acid methyl ester
    3. CAS NO:123227-12-3
    4. Molecular Formula:
    5. Molecular Weight: 463.554
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 123227-12-3.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 11-<<2-<(2-methoxybenzoyl)amino>ethyl>thio>-6,11-dihydrobenzoxepin-2-carboxylic acid methyl ester(CAS DataBase Reference)
    10. NIST Chemistry Reference: 11-<<2-<(2-methoxybenzoyl)amino>ethyl>thio>-6,11-dihydrobenzoxepin-2-carboxylic acid methyl ester(123227-12-3)
    11. EPA Substance Registry System: 11-<<2-<(2-methoxybenzoyl)amino>ethyl>thio>-6,11-dihydrobenzoxepin-2-carboxylic acid methyl ester(123227-12-3)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 123227-12-3(Hazardous Substances Data)

123227-12-3 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 123227-12-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,3,2,2 and 7 respectively; the second part has 2 digits, 1 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 123227-12:
(8*1)+(7*2)+(6*3)+(5*2)+(4*2)+(3*7)+(2*1)+(1*2)=83
83 % 10 = 3
So 123227-12-3 is a valid CAS Registry Number.

123227-12-3Relevant articles and documents

Non-prostanoid thromboxane A2 receptor antagonists with a dibenzoxepin ring system. 1

Ohshima,Takami,Sato,Obase,Miki,Ishii,Karasawa,Kubo

, p. 3394 - 3402 (2007/10/02)

A series of 11-[[2-[(arylsulfonyl)amino]ethyl]thio]-6,11- dihydrodibenz[b,e]oxepin-2-carboxylic acids and related derivatives were synthesized. The compounds were tested for their antagonizing effects on guinea pig platelet TXA2/PGH2 receptors. Structure-activity relationships are discussed. (±)-11-[[2-[(Styrylsulfonyl)amino]ethyl]thio]-6,11- dihydrodibenz[b,e]oxepin-2-carboxylic acid (41) and (±)-11-[[2- [(phenylsulfonyl)amino]ethyl]thio]-6,11-dihydrodibenz[b,e]thiepin-2- carboxylic acid (4af) were the most promising compounds with K(i) values of 6.5 ± 0.29 and 3.7 ± 0.31 nM, respectively, for the TXA2/PGH2 receptor. These compounds also significantly inhibited U-46619-induced guinea pig platelet aggregation ex vivo (10 mg/kg po). Compound 41 was resolved into its optically active form. The (-)-isomer was 60-fold more potent than the (+)- isomer in the TXA2/PGH2 receptor binding assay. Some compounds tested in this study showed both TXA2/PGH2 receptor antagonizing and TXA2 synthase inhibitory effects.

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