1232305-63-3Relevant academic research and scientific papers
Design, synthesis, and biological functionality of a dendrimer-based modular drug delivery platform
Mullen, Douglas G.,McNerny, Daniel Q.,Desai, Ankur,Cheng, Xue-Min,Dimaggio, Stassi C.,Kotlyar, Alina,Zhong, Yueyang,Qin, Suyang,Kelly, Christopher V.,Thomas, Thommey P.,Majoros, Istvan,Orr, Bradford G.,Baker, James R.,Banaszak Holl, Mark M.
experimental part, p. 679 - 689 (2012/03/08)
A modular dendrimer-based drug delivery platform was designed to improve upon existing limitations in single dendrimer systems. Using this modular strategy, a biologically active platform containing receptor mediated targeting and fluorescence imaging modules was synthesized by coupling a folic acid (FA) conjugated dendrimer with a fluorescein isothiocyanate (FITC) conjugated dendrimer. The two different dendrimer modules were coupled via the 1,3-dipolar cycloaddition reaction ("click" chemistry) between an alkyne moiety on the surface of the first dendrimer and an azide moiety on the second dendrimer. Two simplified model systems were also synthesized to develop appropriate "click" reaction conditions and aid in spectroscopic assignments. Conjugates were characterized by 1H NMR spectroscopy and NOESY. The FA-FITC modular platform was evaluated in vitro with a human epithelial cancer cell line (KB) and found to specifically target the overexpressed folic acid receptor.
DENDRIMER BASED MODULAR PLATFORMS
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, (2010/07/04)
The present invention relates to novel therapeutic and diagnostic dendrimer based modular platforms (e.g., drug delivery platforms). In particular, the dendrimer based modular platforms are configured such that two or more dendrimers (e.g., PAMAM dendrimers) are coupled together (e.g., via a cycloaddition reaction) wherein each of the coupled dendrimers is functionalized (e.g., functionalized for targeting, imaging, sensing, and/or providing a therapeutic or diagnostic material and/or monitoring response to therapy). In some embodiments, the present invention provides dendrimer based modular platforms having coupled dendrimers (e.g., two or more coupled dendrimers) wherein each dendrimer is conjugated to one or more functional groups (e.g., therapeutic agent, imaging agent, targeting agent, triggering agent) (e.g., for specific targeting and/or therapeutic use of the dendrimer based modular platform). In some embodiments, the functional groups are conjugated to the dendrimers via a linker and/or a triggering agent. In addition, the present invention is directed to methods of synthesizing dendrimer based modular platforms, compositions comprising the dendrimer based modular platforms, as well as systems and methods utilizing the dendrimer based modular platforms (e.g., in diagnostic and/or therapeutic settings (e.g., for the delivery of therapeutics, imaging, and/or targeting agents (e.g., in disease (e.g., cancer) diagnosis and/or therapy, etc.)).
Isolation and characterization of dendrimers with precise numbers of functional groups
Mullen, Douglas G.,Borgmeier, Emilee L.,Desai, Ankur M.,Van Dongen, Mallory A.,Barash, Mark,Cheng, Xue-Min,Baker Jr., James R.,Banaszak Holl, Mark M.
supporting information; experimental part, p. 10675 - 10678 (2010/11/18)
(Figure Presented) Precision dendrimer: Nine different dendrimer components with precise numbers of a functional ligand were isolated leading to an order of magnitude improvement in the purity of each component.
