1232361-12-4Relevant articles and documents
5-Cyclic amine-3-arylsulfonylindazoles as novel 5-HT6 receptor antagonists
Haydar, Simon N.,Yun, Heedong,Andrae, Patrick M.,Mattes, James,Zhang, Jean,Kramer, Angela,Smith, Deborah L.,Huselton, Christine,Graf, Radka,Aschmies, Suzan,Schechter, Lee E.,Comery, Thomas A.,Robichaud, Albert J.
supporting information; scheme or table, p. 2521 - 2527 (2010/08/22)
Novel 5-cyclic amine-3-arylsulfonylindazoles were prepared, and several analogues within this class have been identified as high-affinity 5-HT 6 receptor ligands with improved pharmacokinetic and pharmacological properties. One selected example, 18b, showed good brain penetrability and a generally favorable pharmacokinetic profile with procognitive efficacy in the rat novel object recognition assay. The synthesis and structure-activity relationship of this potent class are discussed.