123241-42-9

Basic information

• Product Name: Benzonitrile, 2-amino-6-ethoxy-
• Synonyms: Benzonitrile, 2-amino-6-ethoxy-
• CAS NO: 123241-42-9
• Molecular Formula: C₉H₁₀N₂O
• Molecular Weight: 0
• Mol File: 123241-42-9.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Benzonitrile, 2-amino-6-ethoxy-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzonitrile, 2-amino-6-ethoxy-(123241-42-9)
• EPA Substance Registry System: Benzonitrile, 2-amino-6-ethoxy-(123241-42-9)

Safety Data

• Hazardous Substances Data: 123241-42-9(Hazardous Substances Data)

Upstream product

• 123241-32-7 2-ethoxy-6-nitro-benzonitrile 
• 35213-00-4 2,6-dinitrobenzonitrile 
• 606-21-3 1-chloro-2,6-dinitrobenzene 
• 917-58-8 potassium ethoxide 
• 77326-36-4 2-amino-6-fluorobenzonitrile 

Downstream Products

• 119584-81-5 5-ethoxy-2,4-diaminoquinazoline 
• 54166-99-3 2-amino-6-ethoxybenzamide 

Relevant articles and documents

The chemical development of CHIR-258

This paper is a case history of the early stage chemical development of CHIR-258 (4-amino-5-fluoro-3-[6-(4-methyl-1-piperazinyl)-1H-benzimidazol-2-yl]- 2(1H)-quinolinone, DL-lactate salt), a vascular endothelial growth factor (VEGF) kinase inhibitor for t

Antifolate and Antibacterial Activities of 5-Substituted 2,4-Diaminoquinazolines

A series of 5-substituted 2,4-diaminoquinazolines (3) has been synthesized and evaluated as inhibitors of the enzyme dihydrofolate reductase (DHFR) from both bacterial and mammalian sources.The best compounds (e.g. 53) show good activity against Escherichia coli DHFR, but there is no significant selectivity for the bacterial over the mammalian enzyme.The structure-activity relationships for enzyme inhibition appear to be complex and not amenable to simple analysis; a hypotesis to explain the observed qualitative structure-activity relationships is proposed.The inhibitory activities of the compounds against the growth of intact bacterial cells in vitro closely parallel those for the inhibition of the isolated bacterial enzymes, suggesting that their antifolate action is responsible for their antibacterial effects.Five of the compounds were tested for their ability to cure a systemic E. coli infection in the mouse, but they showed no therapeutic effects at their maximum tolerated doses.