123251-25-2

Basic information

• Product Name: 4-benzyloxy-3,5-dimethoxybenzaldehyde bis(phenylthio)acetal
• Synonyms: 4-benzyloxy-3,5-dimethoxybenzaldehyde bis(phenylthio)acetal
• CAS NO: 123251-25-2
• Molecular Weight: 474.645
• Mol File: 123251-25-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-benzyloxy-3,5-dimethoxybenzaldehyde bis(phenylthio)acetal(CAS DataBase Reference)
• NIST Chemistry Reference: 4-benzyloxy-3,5-dimethoxybenzaldehyde bis(phenylthio)acetal(123251-25-2)
• EPA Substance Registry System: 4-benzyloxy-3,5-dimethoxybenzaldehyde bis(phenylthio)acetal(123251-25-2)

Safety Data

• Hazardous Substances Data: 123251-25-2(Hazardous Substances Data)

Upstream product

• 134-96-3 syringic aldehyde 
• 100-44-7 benzyl chloride 
• 6527-32-8 4-(benzyloxy)-3,5-dimethoxybenzaldehyde 
• 108-98-5 thiophenol 

Downstream Products

• 123251-26-3 (+/-)-3-<4'-benzyloxy-3',5'-dimethoxy-α,α-bis(phenylthio)benzyl>butyrolactone 
• 123251-27-4 (+/-)-trans-3-<4'-benzyloxy-3',5'-dimethoxy-α,α-bis(phenylthio)benzyl>-2-(3,4,5-trimethoxybenzyl)butyrolactone 
• 112667-54-6 (+/-)-hernolactone 

Relevant articles and documents

Studies on the Constituents of the Seeds of Hernandia ovigera L. VII. Syntheses of (+/-)-Hernolactone and (+/-)-Hernandin

Two new lignans, hernolactone (1) and hernandin (2), isolated from the seeds of Hernandia ovigera L. were synthesized in racemic forms.Firstly, (+/-)-1 was obtained by utilizing the conjugate addition reaction of 4 with butenolide followed by alkylation with trimethoxybenzyl bromide and subsequent removal of the protecting groups.Synthesis of 2 was pursued using the corresponding 4-phenyl-1,2-dihydronaphthalene lactone (18).The cleavage of the lactone moiety of 18 afforded an unsaturated hydroxy acid (22).Subsequent hydrogenation of 22 followed by acidification with concentrated hydrochloric acid gave isopicrohernandin (21), leaving the 2,3-trans, 3,4-cis hydroxy acid (23), which was lactonized by means of N,N-dicyclohexylcarbodiimide to afford (+/-)-2.Keywords: Hernandia ovigera; hernolactone; hernandin; lignan; dibenzylbutyrolactone lignan; phenyltetralin lignan; isopicrohernandin; Diels-Alder reaction