1232541-99-9Relevant academic research and scientific papers
Exploration of the HDAC2 foot pocket: Synthesis and SAR of substituted N-(2-aminophenyl)benzamides
Bressi, Jerome C.,Jennings, Andy J.,Skene, Robert,Wu, Yiqin,Melkus, Robert,Jong, Ron De,O'Connell, Shawn,Grimshaw, Charles E.,Navre, Marc,Gangloff, Anthony R.
, p. 3142 - 3145 (2010)
A series of N-(2-amino-5-substituted phenyl)benzamides (3-21) were designed, synthesized and evaluated for their inhibition of HDAC2 and their cytotoxicity in HCT116 cancer cells. Multiple compounds from this series demonstrated time-dependent binding kin
