123258-83-3 Usage
Molecular structure
A complex molecular structure containing a benzimidazole ring, a carboxamide group, and a nine-membered azabicyclic ring.
Benzimidazole ring
A heterocyclic aromatic ring system consisting of a six-membered ring with a nitrogen atom at each end, contributing to the compound's stability and potential biological activity.
Carboxamide group
A functional group containing both a carboxyl (-COOH) and an amide (-NH2) group, which may contribute to hydrogen bonding and interactions with biological targets.
Nine-membered azabicyclic ring
A non-planar ring structure with nine atoms, including two nitrogen atoms, which adds complexity to the compound's structure and may influence its biological activity.
Methyl substituent
A small alkyl group (-CH3) attached at the 9th position of the azabicyclo[3.3.1]nonan ring, which can affect the compound's steric properties and interactions with biological targets.
Potential pharmaceutical or biological activities
The compound's structure suggests that it may have interactions with biological targets such as enzymes or receptors, making it a potential candidate for pharmaceutical or biological applications.
Further research and analysis
To determine the full range of properties and potential applications of this compound, additional research and analysis would be required, including studies on its solubility, stability, and bioavailability, as well as its interactions with specific biological targets.
Check Digit Verification of cas no
The CAS Registry Mumber 123258-83-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,3,2,5 and 8 respectively; the second part has 2 digits, 8 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 123258-83:
(8*1)+(7*2)+(6*3)+(5*2)+(4*5)+(3*8)+(2*8)+(1*3)=113
113 % 10 = 3
So 123258-83-3 is a valid CAS Registry Number.
123258-83-3Relevant articles and documents
Synthesis of a New Class of 2,3-Dihydro-2-oxo-1H-benzimidazole-1-carboxylic Acid Derivatives as Highly Potent 5-HT3 Receptor Antagonists
Turconi, Marco,Nicola, Massimo,Quintero, Myrna Gil,Maiocchi, Luciano,Micheletti, Rosella,et al.
, p. 2101 - 2108 (2007/10/02)
A series of 2,3-dihydro-2-oxo-1H-benzimidazole-1-carboxylic acid esters and amides containing a basic azacyclo- or azabicycloalkyl moiety has been synthesized and evaluated for 5-HT3 antagonistic activity in a radioligand binding assay (3>ICS 205930) and in the 5-HT-induced von Bezold-Jarisch reflex in the rat.It was found that endosubstituted azabicycloalkyl derivatives (e.g. 7a, 12a, 12b) were much more active than the corresponding exo analogues (e. g. 7b, 12h, 12i) or azacycloalkyl compounds.Amidic derivatives 12a, 12b, 12c, 12e, 13b, and 13c proved to be about 10 tim es more active than the corresponding ester derivatives 7a, 11a, 7d, 8a, and 8b.In particular, compound 12a (DA 6215) showed a Ki=3.8 nM in the binding test and an ED50=1 nM/kg iv in the von Bezold-Jarisch reflex assay, an activity comparable to that of the reference compound 2 (ICS 205930, Ki=2 nM, ED50=2.1 nM/kg).IR spectroscopy studies in the solid state and in CHCl3 solution revealed the existence of an intramolecular hydrogen bond in 13b, taken as a model compound for this class of substances.A molecular modeling study showed that 12a, in its internal hydrogen-bound conformation, well matches a recently proposed pharmacophoric model for 5-HT3 antagonist activity.
