1232692-96-4Relevant articles and documents
Pd-Catalyzed C?H Alkylation of Arenes Using PyrDipSi, a Transformable and Removable Silicon-Tethered Directing Group
Sarkar, Dhruba,Gevorgyan, Vladimir
supporting information, p. 11201 - 11204 (2016/08/03)
An efficient Pd-catalyzed ortho-C?H alkylation reaction of arenes using a transformable and removable Si-tethered pyridyldiisopropylsilyl (PyrDipSi) directing group has been developed. In addition, the PyrDipSi directing group allows for an efficient sequential double-fold C?H alkylation/oxygenation of arenes to produce meta-alkylated phenols. This directing group can easily be removed or converted into valuable functionalities, such as aryl, iodo, boronic ester, or phenol.
PyDipSi: A general and easily modifiable/traceless Si-tethered directing group for C-H acyloxylation of arenes
Chernyak, Natalia,Dudnik, Alexander S.,Huang, Chunhui,Gevorgyan, Vladimir
supporting information; experimental part, p. 8270 - 8272 (2010/08/04)
A new general and easily installable silicon-tethered pyridyl-containing directing group (PyDipSi) that allows for highly efficient and regioselective Pd-catalyzed ortho C-H acyloxylation of arenes has been developed. It has also been demonstrated that this directing group can efficiently be removed as well as converted into a variety of other valuable functional groups. In addition, the installation of the PyDipSi directing group along with pivaloxylation and quantitative conversion of the PyDipSi group into a halogen functionality represents a formal three-step ortho oxygenation of haloarenes.