1232780-81-2

Basic information

• Product Name: 5-Amino-1-(3,5-difluorophenyl)-1H-pyrazole-4-carbonitrile
• Synonyms: 5-Amino-1-(3,5-difluorophenyl)-1H-pyrazole-4-carbonitrile
• CAS NO: 1232780-81-2
• Molecular Formula: C10H6F2N4
• Molecular Weight: 220.18
• Mol File: 1232780-81-2.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5-Amino-1-(3,5-difluorophenyl)-1H-pyrazole-4-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Amino-1-(3,5-difluorophenyl)-1H-pyrazole-4-carbonitrile(1232780-81-2)
• EPA Substance Registry System: 5-Amino-1-(3,5-difluorophenyl)-1H-pyrazole-4-carbonitrile(1232780-81-2)

Safety Data

• Hazardous Substances Data: 1232780-81-2(Hazardous Substances Data)

Upstream product

• 123-06-8 Ethoxymethylenemalononitrile 
• 134993-88-7 (3,5-difluorophenyl)hydrazine 

Relevant articles and documents

Identification of novel GLUT inhibitors

The compound class of 1H-pyrazolo[3,4-d]pyrimidines was identified using HTS as very potent inhibitors of facilitated glucose transporter 1 (GLUT1). Extensive structure–activity relationship studies (SAR) of each ring system of the molecular framework was established revealing essential structural motives (i.e., ortho-methoxy substituted benzene, piperazine and pyrimidine). The selectivity against GLUT2 was excellent and initial in vitro and in vivo pharmacokinetic (PK) studies are encouraging.