123281-40-3

Upstream product

• 77336-23-3 2,4,6-tribromophenyl-hydrazono-ethyl-2,3-dioxobutyrate 

Downstream Products

• 123306-61-6 4-Chloro-1-(2,4,6-tribromo-phenyl)-1H-pyrazole-3-carboxylic acid ethyl ester 
• 123281-42-5 4-Hydroxy-5-nitro-1-(2,4,6-tribromo-phenyl)-1H-pyrazole-3-carboxylic acid ethyl ester 
• 123281-46-9 4-Nitro-1-(2,4,6-tribromo-phenyl)-1H-pyrazole-3-carboxylic acid ethyl ester 
• 123281-50-5 6-Nitro-5-(2,4,6-tribromo-phenyl)-1,5-dihydro-pyrazolo[4,5-c]pyrazol-3-ol 
• 123281-52-7 3-Chloro-6-nitro-5-(2,4,6-tribromo-phenyl)-1,5-dihydro-pyrazolo[4,5-c]pyrazole 
• 123281-48-1 4-Hydroxy-5-nitro-1-(2,4,6-tribromo-phenyl)-1H-pyrazole-3-carboxylic acid hydrazide 
• 123281-45-8 4-Chloro-5-nitro-1-(2,4,6-tribromo-phenyl)-1H-pyrazole-3-carboxylic acid ethyl ester 

Relevant academic research and scientific papers

Concise and efficient synthesis of 1H-pyrazoles: Reaction of [hydroxy(tosyloxy)iodo]benzene with ethyl 2,3-dioxobutanoate-2-arylhydrazones

Ethyl 2,3-dioxobutanoate-2-arylhydrazones 1 on treatment with [hydroxy(tosyloxy)iodo]benzene 2 at reflux temperature and followed by heating in the presence of N-ethyldiisopropylamine afforded the cyclized ethyl 1-aryl-4-hydroxy-1H-3-pyrazolecarboxylates 4 in good yield.