1232884-92-2Relevant academic research and scientific papers
New retinoid derivatives as back-ups of Adarotene
Giannini, Giuseppe,Brunetti, Tiziana,Battistuzzi, Gianfranco,Alloatti, Domenico,Quattrociocchi, Gianandrea,Cima, Maria Grazia,Merlini, Lucio,Dallavalle, Sabrina,Cincinelli, Raffaella,Nannei, Raffaella,Vesci, Loredana,Bucci, Federica,Foderà, Rosanna,Guglielmi, Mario Berardino,Pisano, Claudio,Cabri, Walter
, p. 2405 - 2415 (2012/05/07)
Adarotene belongs to the so-called class of atypical retinoids. The presence of the phenolic hydroxyl group on Adarotene structure allows a rapid O-glucuronidation as a major mechanism of elimination of the drug, favoring a fast excretion of its glucuronide metabolite in the urines. A series of ether, carbamate and ester derivatives was synthesized. All of them were studied and evaluated for their stability at different pH. The cytotoxic activity in vitro on NCI-H460 non-small cell lung carcinoma and A2780 ovarian tumor cell lines was also tested. A potential back-up of Adarotene has been selected to be evaluated in tumor models.
NEW RETINOID DERIVATIVES ENDOWED WITH CYTOTOXIC AND/OR ANTIANGIOGENIC PROPERTIES
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Page/Page column 20, (2010/07/09)
The present invention relates to new retinoid derivatives of Formula (I), and to pharmaceutical compositions containing them for the treatment of patients affected by pathologies such as arthritic conditions, tumours, metastatic cancer, diabetic retinopathy, psoriasis, chronic inflammatory diseases or atherosclerosis.
