1232885-70-9Relevant academic research and scientific papers
Asymmetric Mukaiyama aldol reaction catalyzed by C2-symmetric N,N′-dioxide-Ni(II)complex
Zhao, Jiannan,Zheng, Ke,Yang, Yang,Shi, Jian,Lin, Lili,Liu, Xiaohua,Feng, Xiaoming
, p. 903 - 906 (2011)
The N,N′-dioxide-Ni(II) complex has been developed for the asymmetric Mukaiyama aldol reaction between glyoxal derivatives and enolsilane which produced the 2-hydroxy-1,4-dicarbonyl compounds in moderate to high yields (up to 95%) with excellent enantiose
Preparation method of chiral 1, 4-diphenyl-2-hydroxy-1, 4-dibutanone compound
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Paragraph 0175-0180, (2021/06/22)
The invention provides a preparation method of a chiral 1, 4-diphenyl-2-hydroxyl-1, 4-dibutanone compound. The method comprises the following steps: in the presence of a chiral metal compound, mixing silyl enol ether and phenylacetaldehyde monohydrate or substituted phenylacetaldehyde monohydrate in a solvent and performing action to obtain the chiral 1, 4-diphenyl-2-hydroxy-1, 4-dibutanone compound, wherein the reaction equation is as shown in the formula 1; R1 of silyl enol ether is of a phenyl or furan structure, a substituent R2 in substituted phenyl glyoxal monohydrate is selected from one or more of hydrogen atoms, halogen, methyl, methoxyl, nitryl and trifluoromethyl, and the substituent is at the ortho-position, meta-position or para-position of a benzene ring. The chiral metal compound can efficiently and highly enantioselectively catalyze the asymmetric Mukaiyama aldol reaction of the phenylacetaldehyde monohydrate compound, a new method for synthesizing the 1, 4-diphenyl-2-hydroxy-1, 4-dibutanone compound is provided, the problem that conditions are harsh in the original reaction is solved, and the chiral metal compound is more environmentally friendly.
Highly enantioselective aza-ene-type reaction catalyzed by chiral N,N′-dioxide-nickel(ii) complex
Zheng, Ke,Liu, Xiaohua,Zhao, Jiannan,Yang, Yang,Lin, Lili,Feng, Xiaoming
supporting information; experimental part, p. 3771 - 3773 (2010/07/06)
An efficient catalytic enantioselective aza-ene-type reaction of glyoxal derivatives with enamides and enecarbamates has been realized using a nickel(ii)-N,N′-dioxide complex as the catalyst.
