1232953-85-3Relevant academic research and scientific papers
Activation of C-F bonds in preference to C-I bonds: Difluoromethylation of lithium enolates with trifluoromethyl iodide
Mikami, Koichi,Tomita, Yuichi,Itoh, Yoshimitsu
supporting information; experimental part, p. 3819 - 3822 (2010/09/04)
(Figure Presented) The l's have it: A conceptually new C-F activation/C-C formation and its mechanism are described. Surprisingly, a reaction with Li-enolates and trifluoromethyl iodide gave (alpha)-difluoromethyl product via C-F bond cleavage in preference to the weaker C-I bond of trifluoromethyliodide. This reaction proceeds without the use of any late transitionmetal catalyst (see scheme; LHMDS = lithium hexamethyldlsilaxide).
