1232975-28-8Relevant articles and documents
Synthesis and structure-activity relationships of a series of (1H-pyrazol-4-yl)acetamide antagonists of the P2X7 receptor
Chambers, Laura J.,Stevens, Alexander J.,Moses, Andrew P.,Michel, Anton D.,Walter, Daryl S.,Davies, David J.,Livermore, David G.,Fonfria, Elena,Demont, Emmanuel H.,Vimal, Mythily,Theobald, Pam J.,Beswick, Paul J.,Gleave, Robert J.,Roman, Shilina A.,Senger, Stefan
scheme or table, p. 3161 - 3164 (2010/09/10)
High-throughput screening identified compound 1 as a potent P2X7 receptor antagonist suitable for lead optimisation. Structure-activity relationships (SAR) of a series of (1H-pyrazol-4-yl)acetamides were investigated and compound 32 was identif