1233045-04-9Relevant academic research and scientific papers
A facile one-pot metal-free synthesis of 1,4-disubstituted 1,2,3-triazoles
Jia, Qianfa,Yang, Gongming,Chen, Lei,Du, Zhiyun,Wei, Jia,Zhong, Yanqiong,Wang, Jian
, p. 3435 - 3440 (2015)
Abstract A 1,3-dipolar cycloaddition reaction of commercially available aldehydes with azides and secondary amines through a one-pot strategy has been developed. This method furnishes 1,4-disubstituted 1,2,3-triazoles in good to excellent yields and high
'Click chemistry' synthesis of a library of 1,2,3-triazole-substituted galactose derivatives and their evaluation against Trypanosoma cruzi and its cell surface trans-sialidase
Carvalho, Ivone,Andrade, Peterson,Campo, Vanessa L.,Guedes, Paulo M.M.,Sesti-Costa, Renata,Silva, Jo?o S.,Schenkman, Sergio,Dedola, Simone,Hill, Lionel,Rejzek, Martin,Nepogodiev, Sergey A.,Field, Robert A.
experimental part, p. 2412 - 2427 (2010/06/19)
Trypanosoma cruzi trans-sialidase (TcTS) plays a key role in the recognition and invasion of host cells and in enabling the parasite to escape the human immune response. To explore this potential drug target, we have synthesized a small library of substra
