1233045-10-7Relevant articles and documents
'Click chemistry' synthesis of a library of 1,2,3-triazole-substituted galactose derivatives and their evaluation against Trypanosoma cruzi and its cell surface trans-sialidase
Carvalho, Ivone,Andrade, Peterson,Campo, Vanessa L.,Guedes, Paulo M.M.,Sesti-Costa, Renata,Silva, Jo?o S.,Schenkman, Sergio,Dedola, Simone,Hill, Lionel,Rejzek, Martin,Nepogodiev, Sergey A.,Field, Robert A.
experimental part, p. 2412 - 2427 (2010/06/19)
Trypanosoma cruzi trans-sialidase (TcTS) plays a key role in the recognition and invasion of host cells and in enabling the parasite to escape the human immune response. To explore this potential drug target, we have synthesized a small library of substra