123311-11-5Relevant articles and documents
Diastereoselective Synthesis of Cyclopropane Amino Acids Using Diazo Compounds Generated in Situ
Adams, Luke A.,Aggarwal, Varinder K.,Bonnert, Roger V.,Bressel, Bettina,Cox, Russell J.,Shepherd, Jon,De Vicente, Javier,Walter, Magnus,Whittingham, William G.,Winn, Caroline L.
, p. 9433 - 9440 (2003)
A simple and high-yielding method for the preparation of cyclopropane amino acids is described. The novel method involves the one-pot cyclopropanation of readily available dehydroamino acids using aryl and unsaturated diazo compounds generated in situ fro
Polymer-supported O-alkylisoureas: Useful reagents for the O-alkylation of carboxylic acids
Crosignani, Stefano,White, Peter D.,Linclau, Bruno
, p. 5897 - 5905 (2007/10/03)
Polymer-supported O-alkylisoureas were prepared by reaction of an alcohol with a polymer-supported carbodiimide under copper(II) catalysis. These reagents were used to transform carboxylic acids into the corresponding methyl, benzyl, allyl, and p-nitrobenzyl esters in a highly chemoselective manner in high yields and in very high purity after simple resin filtration and solvent evaporation. The reactions could be carried out using both conventional or microwave heating, with reaction times as short as 3-5 min in the latter case, without compromising yield, purity, or chemoselectivity. Unfortunately, the corresponding solid-supported tert-butyl isoureas could not be prepared.